Microneme proteins in apicomplexans.
Microneme proteins in apicomplexans.
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DOI：
10.1007/978-0-387-78267-6_2
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发表时间：
2008
影响因子：
--
通讯作者：
V. Carruthers;F. Tomley
中科院分区：
文献类型：
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作者：
V. Carruthers;F. Tomley
大多数顶复合体寄生虫的入侵阶段（zoite）是极化细胞，它们利用放线肌球蛋白驱动的滑翔运动或“滑翔体”系统在表面上移动，通过生物屏障迁移，入侵和离开宿主细胞。这些过程的核心是在寄生虫分泌细胞器（微细胞、异构体）的顶端入侵蛋白被调控释放时，特定受体的及时参与和脱离。在这篇简短的综述中，我们总结了近年来从微元细胞器动员到寄生虫表面的顶端入侵蛋白的鉴定和功能特征的研究进展。我们将重点放在弓形虫、艾美耳虫、隐孢子虫和非红细胞阶段的疟原虫上，因为这些生物是侵入有核细胞的最深入研究的顶复体，因为下一章将讨论红细胞阶段的疟原虫的入侵。
The invasive stages (zoites) of most apicomplexan parasites are polarised cells that use their actinomyosin-powered gliding motility or “glideosome” system to move over surfaces, migrate through biological barriers and invade and leave host cells. Central to these processes is the timely engagement and disengagement of specific receptors upon the regulated release of apical invasion proteins from parasite secretory organelles (micronemes, rhoptries). In this short review, we summarise recent progress on identification and functional characterisation of apical invasion proteins mobilised to the parasite surface from the microneme organelles. We have restricted our focus toToxoplasma, Eimeria, Cryptosporidiumand the nonerythrocytic stages ofPlasmodiumbecause these organisms have been the most intensively studied apicomplexans that invade nucleated cells and because invasion by erythrocytic stages ofPlasmodiumis covered in the next chapter.