Effectiveness of cetuximab/gefitinib in the therapy of a sacral chordoma
Effectiveness of cetuximab/gefitinib in the therapy of a sacral chordoma
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DOI：
10.1159/000096283
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发表时间：
2006-01-01
期刊：
影响因子：
0.3
通讯作者：
Debus, Juergen
中科院分区：
文献类型：
--
作者：
Hof, Holger;Welzel, Thomas;Debus, Juergen
Background: Chordomas are rare tumors of the skull base and the spine. Treatment is difficult since conventional radiotherapy or chemotherapy have only limited effects. Patient and Methods: A patient with a sacral chordoma and pulmonary metastases received initial surgery and radiotherapy for a local recurrence. After 11 months another local recurrence as well as a progression of the pulmonary metastases was documented. As tumor biopsies revealed the expression of the EGF receptor an individual treatment approach with a combination of cetuximab and gefitinib was performed. Results: Under the treatment with cetuximab/gefitinib the local recurrence and the pulmonary metastases showed a partial response over the follow-up period of 9 months. To date no treatment failure was observed. Conclusions: The inhibition of the EGF pathway seems to be an effective measure in the treatment of a chordoma. Further follow-up will have to prove the long-term efficiency.
