SUPPRESSION OF TYPE-II COLLAGEN-INDUCED ARTHRITIS BY INTRAGASTRIC ADMINISTRATION OF SOLUBLE TYPE-II COLLAGEN
SUPPRESSION OF TYPE-II COLLAGEN-INDUCED ARTHRITIS BY INTRAGASTRIC ADMINISTRATION OF SOLUBLE TYPE-II COLLAGEN
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DOI：
10.1073/pnas.83.19.7443
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发表时间：
1986-10-01
影响因子：
11.1
通讯作者：
THORBECKE, GJ
中科院分区：
文献类型：
--
作者：
NAGLERANDERSON, C;BOBER, LA;THORBECKE, GJ
虽然口服蛋白质抗原可能导致特异性免疫无反应性，但这种免疫调节方法尚未应用于自身免疫性疾病模型。II型胶原诱导的关节炎是通过用软骨的主要成分II型胶原免疫在易感小鼠和大鼠中诱导的多发性关节炎的动物模型。在用佐剂中的II型胶原免疫之前，胃内施用可溶性II型胶原抑制胶原诱导的关节炎的发病率。给予变性II型胶原蛋白对疾病的发生率或严重程度没有明显影响。与对照组相比，在胶原蛋白喂养的小鼠中抗体应答的总体幅度没有显著降低。虽然抗胶原蛋白抗体的同种型分布在两组中相似，但在胶原蛋白喂养的小鼠中存在IgG2应答降低的趋势。
Although oral administration of protein antigens may lead to specific immunologic unresponsiveness, this method of immunoregulation has not been applied to models of autoimmune disease. Type II collagen-induced arthritis is an animal model of polyarthritis induced in susceptible mice and rats by immunization with type II collagen, a major component of cartilage. Intragastric administration of soluble type II collagen, prior to immunization with type II collagen in adjuvant, suppresses the incidence of collagen-induced arthritis. Administration of denatured type II collagen has no observable effect on the incidence or severity of the disease. The overall magnitude of the antibody response is not significantly reduced in collagen-fed mice as compared to controls. While the isotype distribution of the anti-collagen antibodies is similar in the two groups, there is a tendency toward reduced IgG2 responses in the collagen-fed mice.