Microbial metabolism of 1-aminoanthracene by Beauveria bassiana.
Microbial metabolism of 1-aminoanthracene by Beauveria bassiana.
复制标题
白僵菌对 1-氨基蒽的微生物代谢。
DOI：
10.1016/j.bmc.2008.03.030
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发表时间：
2008
影响因子：
3.5
通讯作者：
Gunatilaka,AALeslie
中科院分区：
文献类型：
--
作者：
Zhan,Jixun;Gunatilaka,AALeslie
球孢白杆菌ATCC 7159对致癌物和诱变物1-氨基蒽进行了高效代谢，生成3种新的代谢物，分别为1-乙酰氨基-5-[（4 ' - o-甲基-β-d-葡萄糖吡喃基）氧]蒽、1-乙酰氨基-8-[（4 ' - o-甲基-β-d-葡萄糖吡喃基）氧]蒽醌、1-乙酰氨基-6-[（4 ' - o-甲基-β-d-葡萄糖吡喃基）氧]蒽醌、1-乙酰氨基蒽醌和1-乙酰氨基蒽醌。这些代谢物的形成表明，球孢酵母ATCC 7159中1-氨基蒽的代谢途径包括乙酰化、氧化、羟基化和o -甲基糖基化。
The carcinogen and mutagen, 1-aminoanthracene, was efficiently metabolized by the fungal strain Beauveria bassiana ATCC 7159 to yield three new metabolites identified as 1-acetamido-5-[(4′-O-methyl-β-d-glucopyranosyl)oxy]anthracene, 1-acetamido-8-[(4′-O-methyl-β-d-glucopyranosyl)oxy]anthraquinone, and 1-acetamido-6-[(4′-O-methyl-β-d-glucopyranosyl)oxy]anthraquinone, together with 1-acetamidoanthracene and 1-acetamidoanthraquinone. Formation of these metabolites suggests that the metabolic pathways of 1-aminoanthracene in B. bassiana ATCC 7159 involve acetylation, oxidation, hydroxylation, and O-methylglucosylation.