Spectrum of inclusion body myositis.
Spectrum of inclusion body myositis.
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包涵体肌炎谱。
DOI：
10.1001/archneur.1987.00520230042011
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发表时间：
1987
影响因子：
--
通讯作者：
M. Carry
中科院分区：
文献类型：
--
作者：
S. Ringel;Catherine E. Kenny;H. Neville;R. Giorno;M. Carry
描述了一大组包涵体肌炎(IBM)患者的临床、实验室和活检特征(15名男性和4名女性；平均年龄63岁)。肌肉活检标本的定量组织病理学分析显示，与多发性肌炎(PM)和皮肌炎相比，IBM的纤维坏死和血管内膜及血管周围炎症较少，但更常见的是暗角和肥大的纤维。有边框的空泡出现在所有纤维中的3.4%，在11例患者的活检标本中有9例发现了15-18 nm的细丝。一组与淋巴细胞和单核/巨噬细胞系细胞呈免疫反应的单抗表明，IBM的炎症反应与PM相似(但不是皮肌炎)，并由细胞免疫反应介导。这些研究证实了IBM和慢性PM之间的临床和组织病理学差异，并且这些疾病之间的区别通常是困难的。
The clinical, laboratory, and biopsy features are described for a large group of patients with inclusion body myositis (IBM) (15 men and four women; mean age, 63 years). A quantitative histopathologic analysis of muscle biopsy specimens revealed less fiber necrosis and endomysial and perivascular inflammation in IBM than in polymyositis (PM) and dermatomyositis, but a more frequent occurrence of dark-angular and hypertrophied fibers. Rimmed vacuoles were present in 3.4% of all fibers and 15- to 18-nm filaments were identified in the biopsy specimens of nine of 11 patients. A panel of monoclonal antibodies immunoreactive with lymphocytes and cells of monocyte/macrophage lineage suggested that the inflammatory reaction in IBM was similar to that in PM (but not dermatomyositis) and mediated by cellular immune responses. These studies confirm the clinical and histopathologic distinctions between IBM and chronic PM, and that differentiation between these disorders is often difficult.