Natural killer cells regulate Th1/Treg and Th17/Treg balance in chlamydial lung infection.
Natural killer cells regulate Th1/Treg and Th17/Treg balance in chlamydial lung infection.
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自然杀伤细胞调节衣原体肺部感染中的 Th1/Treg 和 Th17/Treg 平衡
DOI：
10.1111/jcmm.12821
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发表时间：
2016-07
影响因子：
5.3
通讯作者：
Zhao W
中科院分区：
文献类型：
--
作者：
Li J;Dong X;Zhao L;Wang X;Wang Y;Yang X;Wang H;Zhao W
自然杀伤细胞(NK细胞)是天然免疫的重要组成部分，通过调节包括T细胞在内的其他免疫细胞的功能，在天然免疫和获得性免疫之间发挥重要作用。在本研究中，我们重点研究了NK细胞在衣原体肺部感染中调节Th1/Treg和Th17/Treg平衡中的作用。我们发现，与同类型对照抗体处理的小鼠相比，NK细胞耗竭的小鼠表现出Th1和Th17细胞的减少，这与干扰素-γ、IL-12、IL-17和IL-22的产生以及T-bet和受体相关的孤儿受体γt的表达减少有关。相反，去NK细胞显著增加Treg细胞数量和相关转录因子(Foxp3)的表达。Th1/Th17和Treg的变化趋势相反，导致Th1/Treg和Th17/Treg比值显著降低。结果提示，NK细胞主要通过维持Th1/Treg和Th17/Treg的平衡，在机体抵御衣原体肺部感染中发挥重要作用。
Natural killer (NK) cell is an important component in innate immunity, playing a critical role in bridging innate and adaptive immunity by modulating the function of other immune cells including T cells. In this study, we focused on the role of NK cells in regulating Th1/Treg and Th17/Treg balance during chlamydial lung infection. We found that NK cell‐depleted mice showed decreased Th1 and Th17 cells, which was correlated with reduced interferon‐γ, interleukin (IL)‐12, IL‐17 and IL‐22 production as well as T‐bet and receptor‐related orphan receptor gamma t expression compared with mice treated with the isotype control antibody. In contrast, NK cell depletion significantly increased Treg in cell number and related transcription factor (Foxp3) expression. The opposite trends of changes of Th1/Th17 and Treg led to significant reduction in the Th1/Treg and Th17/Treg ratios. The data implicate that NK cells play an important role in host defence against chlamydial lung infection, mainly through maintaining Th1/Treg and Th17/Treg balance.