Insulin-Like Growth Factor 1 Treatment of MSCs Attenuates Inflammation and Cardiac Dysfunction Following MI
Insulin-Like Growth Factor 1 Treatment of MSCs Attenuates Inflammation and Cardiac Dysfunction Following MI
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DOI：
10.1007/s10753-014-9949-3
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发表时间：
2014-12-01
期刊：
影响因子：
5.1
通讯作者：
Li, Zi-cheng
中科院分区：
文献类型：
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作者：
Guo, Jun;Zheng, Dong;Li, Zi-cheng
据报道，胰岛素样生长因子1（IGF-1）促进内皮细胞和心脏驻留祖细胞的迁移。在前期研究中，我们发现IGF-1对体外培养的MSCs中CXCR 4表达的影响具有时间和剂量依赖性，但IGF-1预处理MSCs是否能在心肌梗死中发挥抗凋亡和抗炎作用尚不清楚。在这项研究中，我们证明了IGF-1处理的MSC移植减轻心功能不全，增加移植细胞在缺血心脏中的存活，减少心肌细胞凋亡，并抑制炎症细胞因子肿瘤坏死因子α（TNF-α），白细胞介素（IL）-1 β和IL-6的蛋白质产生和基因表达。IGF-1预处理MSCs可能在心肌梗死后发挥抗凋亡和抗炎作用。
It has been reported that insulin-like growth factor 1 (IGF-1) promoted migration of endothelial cells and cardiac resident progenitor cells. In the previous study, we found the time-dependent and dose-dependent effects of IGF-1 treatment on the CXCR4 expression in MSCs in vitro, but it is still not clear whether IGF-1 pretreatment of MSCs may play anti-apoptotic and anti-inflammation role in myocardial infarction. In this study, we demonstrated that IGF-1-treated MSCs' transplantation attenuate cardiac dysfunction, increase the survival of engrafted cells in the ischemic heart, decrease myocardium cells apoptosis, and inhibit protein production and gene expression of inflammation cytokines tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6. IGF-1 pretreatment of MSCs may play anti-apoptotic and anti-inflammation roles in post-myocardial infarction.