1,25-Dihydroxyvitamin D3 enhances systemic and mucosal immune responses to inactivated poliovirus vaccine in mice
1,25-Dihydroxyvitamin D3 enhances systemic and mucosal immune responses to inactivated poliovirus vaccine in mice
复制标题
DOI：
10.1086/499970
复制
发表时间：
2006-02-15
影响因子：
6.4
通讯作者：
Chumakov, KM
中科院分区：
文献类型：
--
作者：
Ivanov, AP;Dragunsky, EM;Chumakov, KM
1，25-二羟基维生素D3（DHVD 3）与所有3种血清型的单价灭活脊髓灰质炎病毒疫苗（IPV）联合给药可显著增强小鼠的抗脊髓灰质炎病毒全身和粘膜免疫力。尽管血清免疫球蛋白G抗体在血清型2和3中显著更高，并且尽管唾液免疫球蛋白A在血清型1和3中显著增加，但DHVD 3对所有3种IPV血清型的中和血清抗体水平具有最显著的影响。这些研究结果表明，维生素D3可能用作目前使用和拟议的新Sabin IPV的佐剂。
1,25-Dihydroxyvitamin D3 (DHVD3) coadministered with monovalent inactivated poliovirus vaccine (IPV) of all 3 serotypes significantly enhances antipoliovirus systemic and mucosal immunity in mice. Although serum immunoglobulin G antibodies are significantly higher in serotypes 2 and 3, and although salivary immunoglobulin A is significantly increased in serotypes 1 and 3, DHVD3 had the most dramatic effect on the level of neutralizing serum antibodies of all 3 IPV serotypes. These findings suggest a possible use of vitamin D3 as an adjuvant for currently used and proposed new Sabin IPVs.