Cellular targeting and segregation of bacterial chemosensory systems.
Cellular targeting and segregation of bacterial chemosensory systems.
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DOI：
10.1093/femsre/fuy015
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发表时间：
2018-06
影响因子：
11.3
通讯作者：
Emilia M. F. Mauriello;Christopher W. Jones;A. Moine;J. Armitage
中科院分区：
文献类型：
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作者：
Emilia M. F. Mauriello;Christopher W. Jones;A. Moine;J. Armitage
细菌细胞质不是大分子的均质溶液，而是高度组织和分隔的空间，其中某些细胞区域中大分子复合物的聚集和分离赋予了功能效率。细菌化学感受器代表了研究大分子亚细胞定位的通用模型系统，因为它们存在于几乎所有能运动的细菌和古细菌物种中，它们倾向于形成高度有序的阵列，占据细胞中的不同位置。化学感受器簇的定位及其在细胞分裂中的分离机制因物种而异，并且可能取决于细胞大小、环境和运动速度。在这篇综述中，我们总结了目前对有限数量的细菌模型系统中化学感受器的结构和分离机制的理解，并表明化学感受器的分布模式与该物种的行为生活方式相关。
The bacterial cytoplasm is not a homogeneous solution of macromolecules, but rather a highly organized and compartmentalized space where the clustering and segregation of macromolecular complexes in certain cell regions confers functional efficiency. Bacterial chemoreceptors represent a versatile model system to study the subcellular localization of macromolecules, as they are present in almost all motile bacterial and archaeal species, where they tend to form highly ordered arrays that occupy distinct positions in cells. The positioning of chemoreceptor clusters, as well as their segregation mechanism on cell division, varies from species to species and probably depends on cells size, environment and speed of movement. In this review, we summarize the current understanding of the architecture and the segregation mechanisms of chemoreceptors in a limited number of bacterial model systems and suggest that the pattern of chemoreceptor distribution is coupled to behavioral life-style of that species.