Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes
Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes
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DOI：
10.1016/j.diabres.2011.07.002
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发表时间：
2011-11-01
影响因子：
5.1
通讯作者：
Sugimoto, Toshitsugu
中科院分区：
文献类型：
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作者：
Hayashi, Kumi;Kurioka, Soichi;Sugimoto, Toshitsugu
本研究旨在探讨2型糖尿病患者的认知功能与海马和全脑萎缩、年龄、教育程度和糖尿病相关参数的关系，纳入61例65岁以上的2型糖尿病患者和53例年龄和性别匹配的非糖尿病对照。通过脑磁共振成像定量海马和脑体积来评估海马和全脑萎缩。采用简易精神状态检查量表（MMSE）和长谷川痴呆量表（HDS-R）评定认知功能，与非糖尿病组比较，2型糖尿病组海马和全脑萎缩程度明显增加。2型糖尿病患者MMSE和HDS-R评分与年龄呈显著负相关，与受教育年限呈显著正相关。这些分数也与海马萎缩呈显著负相关，但与全脑萎缩无关。然而，糖尿病患者的海马萎缩与年龄、受教育年限或糖尿病相关参数无关，我们发现老年2型糖尿病患者海马和全脑萎缩比非糖尿病对照组更常见。认知功能与海马萎缩呈显著负相关。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
This study aimed to examine the associations of cognitive function with hippocampal and whole brain atrophies, age, education, and diabetes-related parameters in patients with type 2 diabetes.Sixty-one patients over 65 years of age with type 2 diabetes and 53 age-and sex-matched non-diabetic controls were enrolled. Hippocampal and whole brain atrophies were assessed by quantifying hippocampal and brain volumes by brain magnetic resonance imaging. Cognitive function was evaluated by Mini-Mental State Examination (MMSE) and the Revised Hasegawa Dementia Scale (HDS-R).Compared with the non-diabetic group, patients with type 2 diabetes showed significant increases in hippocampal and whole brain atrophies. The MMSE and HDS-R scores in type 2 diabetic patients showed significant negative correlations with age and significant positive correlations with years of education. These scores were also significantly negatively correlated with hippocampal atrophy, but not whole brain atrophy. Hippocampal atrophy in diabetic patients did not, however, correlate with age, years of education, or diabetes-related parameters.We showed hippocampal and whole brain atrophies to be more frequent in elderly patients with type 2 diabetes than in non-diabetic controls. Their cognitive functions were significantly and negatively associated with hippocampal atrophy. (C) 2011 Elsevier Ireland Ltd. All rights reserved.