Pathological Findings in Dogs with Fatal Heatstroke
Pathological Findings in Dogs with Fatal Heatstroke
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DOI：
10.1016/j.jcpa.2008.07.011
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发表时间：
2009-02-01
影响因子：
0.8
通讯作者：
Aroch, I.
中科院分区：
文献类型：
--
作者：
Bruchim, Y.;Loeb, E.;Aroch, I.
对11只中暑致死的犬进行了大体和组织病理学检查。所有患者均表现出多器官出血素质伴凝固性坏死。在皮肤（8只犬）、肺（11只犬）、脑（11只犬）和骨髓中观察到低血容量和弥漫性水肿。还观察到脾髓（10只犬）和肝窦（9只）充血。在小肠（7只犬）、大肠（8只）、肾小管上皮（9只）、肝实质（8只）和脑神经组织（4只）的粘膜中观察到坏死。结果表明，自然发生的，致命的犬中暑引起急性多器官病变，影响大多数身体系统，并建议，更普遍的病变包括出血素质，微血栓形成和凝固性坏死。这些可能是高血压引起的弥散性血管内凝血和全身炎症反应综合征的后遗症，导致多器官功能障碍和死亡。
Eleven dogs with fatal heatstroke were examined grossly and histopathologically post mortem. All showed multi-organ haemorrhagic diathesis with coagulative necrosis. Hypacremia and diffuse oedema were observed n the skin (eight dogs), lungs (11), brain (11) and bone marrow bone). Congestion of the splenic pulp (10 dogs) and hepatic sinusoids (nine) was also noted. Necrosis was observed in the mucosa of the small intestine (seven dogs), large intestine (eight), renal tubular epithelium (nine), hepatic parenchyma (eight) and brain neural tissue (four). The results showed that naturally occurring, fatal canine heatstroke induces acute multiple organ lesions affecting most body systems, and suggest that the more prevalent lesions include haemorrhagic diathesis, microthrombosis and coagulative necrosis. These are probable sequels of hyperthermia-induced disseminated intravascular coagulation and systemic inflammatory response syndrome, which lead to multi-organ dysfunction and death.