THE EFFECT OF DIETARY RESTRICTION OF VARYING DURATION ON SURVIVAL, TUMOR PATTERNS, IMMUNE FUNCTION, AND BODY-TEMPERATURE IN B10C3F1 FEMALE MICE
THE EFFECT OF DIETARY RESTRICTION OF VARYING DURATION ON SURVIVAL, TUMOR PATTERNS, IMMUNE FUNCTION, AND BODY-TEMPERATURE IN B10C3F1 FEMALE MICE
复制标题
DOI：
10.1093/geronj/38.4.420
复制
发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
WALFORD, RL
中科院分区：
文献类型：
--
作者：
CHENEY, KE;LIU, RK;WALFORD, RL
七组小鼠维持在不同的饮食计划上，这些饮食计划在生命的各个阶段的限制方面有所不同。限制与年龄相关的T细胞依赖性免疫功能下降较少，体温略有但显着降低。最好的平均和最大的生存率和最低的晚年死亡率被发现在整个生命限制组，但限制在任何部分的寿命提高生存在某种程度上。荷瘤动物的平均寿命往往是更大的限制比在非限制组，相应的年龄减速效应。肿瘤发生率随限制发生的生命周期而变化，并且在限制动物中并不总是减少。后者的结果表明，饮食限制影响衰老速度和肿瘤易感性的机制可能并不完全相同。
Seven groups of mice were maintained on different dietary programs varying with respect to restrictions at various stages of life. Restriction was associated with less age-related decline in T-cell-dependent immunological function and a slight but significant lowering of body temperature. The best mean and maximal survival and the lowest late-life mortality rate was found in the group restricted throughout life, but restriction during any part of the lifespan enhanced survival to some degree. The mean life spans of tumor-bearing animals tended to be greater in resticted than in nonrestricted groups, corresponding to an age-decelerating effect. Tumor frequency varied with the period of life during which restriction took place and was not always decreased in restricted animals. These latter results suggest that the mechanisms whereby dietary restriction influences the aging rate and tumor susceptibility may not be entirely identical.