Doxorubicin magnetic conjugate targeting upon intravenous injection into mice: High gradient magnetic field inhibits the clearance of nanoparticles from the blood
Doxorubicin magnetic conjugate targeting upon intravenous injection into mice: High gradient magnetic field inhibits the clearance of nanoparticles from the blood
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DOI：
10.1016/j.jmmm.2005.01.063
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发表时间：
2005-05-01
影响因子：
2.7
通讯作者：
Dudchenko, A
中科院分区：
文献类型：
--
作者：
Mykhaylyk, O;Dudchenko, N;Dudchenko, A
通过使用电子自旋共振（ESR）的药代动力学研究来确定固定磁场（竖线del B竖线= 200 mT/cm）在增加阿霉素磁铁矿纳米颗粒缀合物（直径为24 +/-19 nm）在小鼠肺中的生物利用度方面的效率。还发现磁场抑制纳米颗粒从血液中的消除，并增加血液中的缀合物半衰期和生物利用度。(c)2005 Elsevier B. V.保留所有权利。
The efficiency of a stationary magnetic field (vertical bar del B vertical bar = 200 mT/cm) in increasing the bioavailability of a doxorubicinmagnetite nanoparticle conjugate (diameter of 24 +/- 19nm) in the mouse lung was determined by pharmacokinetic investigation using electron spin resonance (ESR). The magnetic field was also found to inhibit the elimination of nanoparticles from the blood and increase the conjugate half-life and bioavailability in the blood. (c) 2005 Elsevier B.V. All rights reserved.