Transmission of viruses via our microbiomes
Transmission of viruses via our microbiomes
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DOI：
10.1186/s40168-016-0212-z
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发表时间：
2016-12-02
期刊：
影响因子：
15.5
通讯作者：
Pride, David T.
中科院分区：
文献类型：
--
作者：
Ly, Melissa;Jones, Marcus B.;Pride, David T.
背景：生活在人体内的细菌在许多生理过程中起着重要的作用，并且已知在遗传相关的个体中是共有的。我们对寄居在人体内的病毒知之甚少，但它们的生态学表明它们可能在密切接触者之间共享。结果：在这里，我们报告了一个队列中肠道和口腔病毒的生态学，并证明了大量的肠道和口腔病毒在遗传上不相关的同居个体之间共享。这些病毒中的大多数都是噬菌体，每个个体都与他们的室友有不同的口腔和肠道病毒生态，尽管他们的一些噬菌体是共享的。噬菌体在家庭内随时间的分布表明，它们经常在家庭接触者的微生物群之间传播。结论：由于噬菌体可能塑造人类口腔和肠道细菌生态，它们向家庭接触者的传播表明它们可能在家庭内微生物区系的形成中发挥重要作用。
Background: Bacteria inhabiting the human body have important roles in a number of physiological processes and are known to be shared amongst genetically-related individuals. Far less is known about viruses inhabiting the human body, but their ecology suggests they may be shared between close contacts.Results: Here, we report the ecology of viruses in the guts and mouths of a cohort and demonstrate that substantial numbers of gut and oral viruses were shared amongst genetically unrelated, cohabitating individuals. Most of these viruses were bacteriophages, and each individual had distinct oral and gut viral ecology from their housemates despite the fact that some of their bacteriophages were shared. The distribution of bacteriophages over time within households indicated that they were frequently transmitted between the microbiomes of household contacts.Conclusions: Because bacteriophages may shape human oral and gut bacterial ecology, their transmission to household contacts suggests they could have substantial roles in shaping the microbiota within a household.