Relationship between Spinal Cord Volume and Spinal Cord Injury due to Spinal Shortening.
Relationship between Spinal Cord Volume and Spinal Cord Injury due to Spinal Shortening.
复制标题
DOI：
10.1371/journal.pone.0127624
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Xia LH
中科院分区：
文献类型：
--
作者：
Qiu F;Yang JC;Ma XY;Xu JJ;Yang QL;Zhou X;Xiao YS;Hu HS;Xia LH
脊柱切除与脊髓损伤的风险有关。在本研究中，我们利用山羊模型，研究脊髓体积的变化与脊髓缩短引起的脊髓损伤之间的关系，并对每1 mm高度的脊髓体积进行量化，以明确缩短的安全限度。10只山羊在T10行脊柱切除。脊髓被缩短，直到体感诱发电位比基线幅度降低50%或相对于基线峰潜伏期延迟10%。术后进行唤醒实验，并观察两天。术前、术后测量脊髓体积、T10高度、椎间隙高度、截骨节段高度、脊柱节段高度。排除了10只山羊中的2只，因此，只分析了8只山羊的数据。这8只山羊的体感诱发电位显示出有意义的变化。在神经功能方面，术后两天分别有5只和3只山羊被评为Tarlov 5级和4级。平均缩短距离为2 3.6±1.5 1 mm，与截骨节段每1 mm高度脊髓体积的d值相关(r=0.95，P<0.001.0 1)，与T10椎体高度相关(r=0.79，P=0.0 2)。截骨节段每1 mm高度脊髓体积的平均d值(术前)为142.87±0.59mm3(范围142.19~143.67 mm3)。截短的极限大约是椎体高度的106%。截骨节段和脊柱节段的平均体积术后无明显变化(t=0.310，p=0.765和t=1.241，p=0.255)。因此，我们的结果表明，缩短的安全限度可以通过每1 mm高度脊髓体积的变化来计算。
Vertebral column resection is associated with a risk of spinal cord injury. In the present study, using a goat model, we aimed to investigate the relationship between changes in spinal cord volume and spinal cord injury due to spinal shortening, and to quantify the spinal cord volume per 1-mm height in order to clarify a safe limit for shortening. Vertebral column resection was performed at T10 in 10 goats. The spinal cord was shortened until the somatosensory-evoked potential was decreased by 50% from the baseline amplitude or delayed by 10% relative to the baseline peak latency. A wake-up test was performed, and the goats were observed for two days postoperatively. Magnetic resonance imaging was used to measure the spinal cord volume, T10 height, disc height, osteotomy segment height, and spinal segment height pre- and postoperatively. Two of the 10 goats were excluded, and hence, only data from eight goats were analyzed. The somatosensory-evoked potential of these eight goats demonstrated meaningful changes. With regard to neurologic function, five and three goats were classified as Tarlov grades 5 and 4 at two days postoperatively. The mean shortening distance was 23.6 ± 1.51 mm, which correlated with the d-value (post-pre) of the spinal cord volume per 1-mm height of the osteotomy segment (r = 0.95, p < 0.001) and with the height of the T10 body (r = 0.79, p = 0.02). The mean d-value (post-pre) of the spinal cord volume per 1-mm height of the osteotomy segment was 142.87 ± 0.59 mm3 (range, 142.19–143.67 mm3). The limit for shortening was approximately 106% of the vertebral height. The mean volumes of the osteotomy and spinal segments did not significantly change after surgery (t = 0.310, p = 0.765 and t = 1.241, p = 0.255, respectively). Thus, our results indicate that the safe limit for shortening can be calculated using the change in spinal cord volume per 1-mm height.
登录
查看更多内容
影响因子：
3
作者：
Braun, John T.;Hoffman, Michael;Bachus, Kent N.
通讯作者：
Bachus, Kent N.
影响因子：
3
作者：
Liljenqvist, UR;Link, TM;Halm, HFH
通讯作者：
Halm, HFH
影响因子：
9.8
作者：
Hermanns, H.;Lipfert, P.;Stevens, M. F.
通讯作者：
Stevens, M. F.
影响因子：
5.3
作者：
Modi, Hitesh N.;Suh, Seung-Woo;Yang, Jae-Hyuk
通讯作者：
Yang, Jae-Hyuk
影响因子：
3
作者：
Bridwell, Keith H.
通讯作者：
Bridwell, Keith H.