The scanning model for translation: an update.
The scanning model for translation: an update.
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DOI：
10.1083/jcb.108.2.229
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发表时间：
1989-02
期刊：
影响因子：
--
通讯作者：
Kozak M
中科院分区：
文献类型：
--
作者：
Kozak M
真核生物核糖体的小亚基(40S)最初与信使RNA的5‘端结合，然后迁移，在第一个8月密码子停止，有利于启动翻译。第一条8月规则不是绝对的，但有违反规则的规则。一些似乎与扫描机制相矛盾的异常观察现在似乎是人工制品。一些真正的反常现象仍未得到解释。
The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained.