Minimizing Carry-Over Effects After Treatment Failure and Maximizing Therapeutic Outcome Can Changing the Route of Administration Mitigate the Influence of Treatment History?
Minimizing Carry-Over Effects After Treatment Failure and Maximizing Therapeutic Outcome Can Changing the Route of Administration Mitigate the Influence of Treatment History?
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DOI：
10.1027/2151-2604/a000180
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发表时间：
2014-01-01
影响因子：
1.8
通讯作者：
Bingel, Ulrike
中科院分区：
文献类型：
--
作者：
Hofmann, Mareile;Wrobel, Nathalie;Bingel, Ulrike
根据实验和临床证据，以前治疗的经验会被带到不同的治疗方法上，并影响后续治疗的结果。在这项行为先导性研究中，我们使用给药途径的改变来调查先前治疗经验对后续治疗的影响是否取决于两种治疗方法的相似性。我们在两组健康受试者身上进行了局部止痛治疗，实验中诱导了积极或消极的体验。随后，我们比较了阳性组和阴性组对第二次无关的全身止痛治疗的反应。我们发现两组在第二次治疗的止痛反应上没有差异。我们的数据表明，改变给药途径可能会减少治疗历史的影响，因此是一种减少治疗失败后的负面遗留效应的方法。未来的研究将不得不在完全平衡的设计中验证这些发现，包括更大的临床样本。
According to experimental and clinical evidence, the experiences of previous treatments are carried over to different therapeutic approaches and impair the outcome of subsequent treatments. In this behavioral pilot study we used a change in administration route to investigate whether the effect of prior treatment experience on a subsequent treatment depends on the similarity of both treatments. We experimentally induced positive or negative experiences with a topical analgesic treatment in two groups of healthy human subjects. Subsequently, we compared responses to a second, unrelated and systemic analgesic treatment between both the positive and negative group. We found that there was no difference in the analgesic response to the second treatment between the two groups. Our data indicate that a change in administration route might reduce the influence of treatment history and therefore be a way to reduce negative carry-over effects after treatment failure. Future studies will have to validate these findings in a fully balanced design including larger, clinical samples.