Spatio-Temporal Information Correction Mechanism for Wild Animal Wearable Sensors
Spatio-Temporal Information Correction Mechanism for Wild Animal Wearable Sensors
复制标题
野生动物可穿戴传感器的时空信息校正机制
DOI：
10.1145/2938559.2948835
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Hiroki Kobayashi
中科院分区：
文献类型：
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作者：
Yuya Kamma;Kaoru Sezaki;Hiroki Kobayashi
背景：重性抑郁症是世界范围内流行的最严重的衰弱性疾病之一。氯胺酮是一种对抑郁症有快速作用的NMDA受体拮抗剂。目的：亚麻醉剂量氯胺酮对抑郁症的不同症状均有疗效。在这里，我们将研究亚麻醉剂量的氯胺酮对各种精神病理学变量的影响，包括抑郁症状，焦虑症状和疾病严重程度，以及对严重抑郁症男性患者重复注射剂量后的即时效应和延迟效应。方法：20例患者的开放标签研究（19例完成研究）男性，诊断为重度抑郁症，既往无精神病、头部损伤、器质性疾病病史，无心脏病史、无药物使用、4周后入院，在基线时进行评估，然后以0.5 mg/kg剂量静脉推注盐酸氯胺酮注射液，在首次给药后1小时进行评估，在两周内以类似方式共给药6次。结果：治疗2周后，患者的HAM-D、HAM-A和CGI-疾病严重程度较治疗前明显降低。而HAM-D和HAM-A在第一小时的得分变化显著。不良反应是轻微的，短暂的，并在一个小时内消退氯胺酮injection.Conclusion：氯胺酮有强大的和快速的效果，抑郁和焦虑症状，以及这种改善是持续与重复给药后两周，有整体下降，疾病的严重程度与重复给药，它也是耐受性良好的剂量为0.5 mg/kg静脉推注。
Background: Major depressive disorder is one of the most debilitating condition prevalent worldwide. Ketamine is NMDA receptor antagonist having rapid action on depressive symptoms.Objectives: Ketamine at subanesthetic doses have effect on different symptoms in depressive disorders. Here we will examine the effects of subanesthetic dose of ketamine on various psychopathology variables in terms of depressive symptoms, anxiety symptoms, and illness severity comprehensively in terms of immediate effect and delayed effect after repeated doses of injection on male patients of severe depression.Methodology: A open label study of 20 patients (19 completed the study) of male sex, with a diagnosis severe depression, having no previous history of psychotic disorder, head injury, organic disorder, substance use and drug free for 4 weeks, having no cardiological problem were admitted in patient, assessments were done at baseline then injection ketamine hydrochloride was given at dose of 0.5 mg/kg intravenous bolus, assessments were done at 1 hour of first dose, total 6 doses were given in similar pattern over two weeks. After two weeks final assessment was done.Results: There is significant lowering of HAM-D, HAM-A and CGI-severity of illness from baseline to two weeks. Whereas change in scores at first hour is significant for HAM-D and HAM-A. Adverse effects seen are mild and transient and subsided within one hour of ketamine injection.Conclusion: Ketamine has robust and rapid effect on depressive and anxiety symptoms as well as this improvement is sustained with repeated dosing after two weeks and there is overall decrease in illness severity with repeated dosing and it is also well tolerated in dose of 0.5 mg/kg given intravenous bolus.