The Spermatogonial Stem Cell Niche
The Spermatogonial Stem Cell Niche
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DOI：
10.1002/jemt.20699
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发表时间：
2009-08-01
影响因子：
2.5
通讯作者：
De Rooij, Dirk G.
中科院分区：
文献类型：
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作者：
De Rooij, Dirk G.
精原干细胞（SSCs; A（s）精原细胞）及其直接后代（A（pr）和A（al）精原细胞）优先位于与间质组织接壤的曲细精管区域。这些细胞较少存在于直接邻接另一个小管的小管区域。因此，SSC生态位与间质组织的存在有关。生精小管内的体细胞，即支持细胞，能够产生刺激SSC的自我更新（GDNF、FGF 2）和分化（激活素A、BMP 4和SCF）的生长因子。由于支持细胞在小管的基底膜上到处都是，来自小管外部的其他因素必须直接或间接地通过支持细胞决定在特定区域中是否优选SSC的自我更新或以Apr形成的形式分化。自我更新在干细胞龛中和龛外的分化中将是优选的。可能将小生境与间质组织联系起来的因素是CSF 1，由Leydig细胞产生，刺激干细胞增殖和FSH，其浓度在血管附近最高，刺激Sertoli细胞产生GDNF。Microsc. Res. Tech. 72：580- 585，2009. (C)2009年威利-利斯。Inc.
Spermatogonial stem cells (SSCs; A(s) spermatogonia) and their direct descendants (A(pr) and A(al) spermatogonia) are preferentially located in those areas of the seminiferous tubules that border on the interstitial tissue. Fewer of these cells are present in tubule areas directly bordering on another tubule. Therefore, the SSC niche is related to the presence of interstitial tissue. The somatic cells within the seminiferous tubules, the Sertoli cells, are able to produce growth factors that stimulate self-renewal (GDNF, FGF2) and differentiation (activin A, BMP4, and SCF) of the SSCs. As Sertoli cells are everywhere on the basal membrane of the tubules, other factors coming from outside the tubules must determine, either directly or indirectly via Sertoli cells, whether in a particular area self-renewal of SSCs will be preferred or differentiation in the form of Apr formation. Self-renewal will be preferred in the stem cell niche and differentiation outside of the niche. Factors that could link the niche to the interstitial tissue are CSF1, produced by Leydig cells that stimulate stem cell proliferation and FSH, the concentration of which will be highest near blood vessels and that stimulates GDNF production by Sertoli cells. Microsc. Res. Tech. 72:580-585,2009. (C) 2009 Wiley-Liss. Inc.