Esthesioneuroblastoma
Esthesioneuroblastoma
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DOI：
10.1016/j.nec.2012.08.005
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发表时间：
2013-01-01
影响因子：
2.6
通讯作者：
Hanna, Ehab Y.
中科院分区：
文献类型：
--
作者：
Ow, Thomas J.;Bell, Diana;Hanna, Ehab Y.
感觉神经母细胞瘤是一种罕见的恶性肿瘤，发生于鼻腔和前颅底嗅区。诊断和分期需要解剖成像和仔细的病理评估。标准治疗是前颅面切除术并术后放疗。化疗的作用尚未明确，但通常适用于最晚期的病例，并用于新辅助治疗和/或术后放疗。预后良好；然而，转移率仍然相对较高。区域和远处转移预示着不良结果。调强放射治疗和内窥镜手术降低了发病率，但必须充分评估这些技术的结果。
Esthesioneuroblastoma is a rare malignant neoplasm in the olfactory region of the nasal cavity and anterior skull base. Diagnosis and staging require anatomic imaging and careful pathologic assessment. Standard treatment is anterior craniofacial resection with postoperative irradiation. The role for chemotherapy is not defined, but is generally for the most advanced cases and used in the neoadjuvant setting and/or postoperatively with irradiation. Prognosis is favorable; however, metastasis rates remain relatively high. Regional and distant metastasis portends a poor outcome. Intensity-modulated radiation treatment and endoscopic surgery have reduced morbidity, but outcomes with these techniques must be fully evaluated.