Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: The Hokkaido Study
Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: The Hokkaido Study
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DOI：
10.1016/j.scitotenv.2015.10.017
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发表时间：
2016-01-15
影响因子：
9.8
通讯作者：
Kishi, Reiko
中科院分区：
文献类型：
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作者：
Goudarzi, Houman;Nakajima, Sonomi;Kishi, Reiko
全氟化学品 (PFC) 是一种普遍存在的持久性污染物，在全球动物和人类的血液样本中广泛检测到。尽管动物研究表明全氟化碳具有潜在的神经毒性，但关于全氟化碳对人类神经系统影响的流行病学研究很少，而且这些研究的结果尚无定论。在这项研究中，我们在 2002 年至 2005 年间进行了一项以医院为基础的前瞻性出生队列研究 (n = 514)，以检查产前全氟辛烷磺酸 (PFOS) 和全氟辛酸 (PFOA) 暴露与 6 (n = 173) 和 18 (n = 133) 个月婴儿神经发育之间的关系。使用第二版婴儿发育贝利量表 (BSID II)，评估心理和精神运动发育指数（分别为 MDI 和 PDI）。采用液相色谱-串联质谱法测定母体血清样品中的 PFOS 和 PFOA。控制混杂因素后，产前 PFOA 浓度与 6 个月大的女婴（而非男婴）的 MDI 相关（β = -0.296；95% 置信区间 (CI)：-11.96，-0.682）。此外，产前 PFOA 浓度处于第四个四分位的母亲所生的女性的 MDI 评分比 PFOA 浓度处于第一个四分位的母亲所生的女性低 -5.05（95% CI：-10.66 至 0.55）（趋势 p = 0.045）。然而，PFOA 浓度与 18 个月龄时的神经发育指标没有显着相关性。此外，我们没有观察到 PFOS 浓度与婴儿早期神经发育结果之间存在任何显着关联。总之，我们的结果表明，产前 PFOA 暴露可能会影响 6 个月大时女性神经发育的心理量表。需要更大样本量和更长观察期的进一步研究来阐明神经发育影响的性别差异。 (C) 2015 Elsevier B.V. 保留所有权利。
Perfluorinated chemicals (PFCs) are ubiquitous and persistent pollutants widely detected in blood samples of animals and humans across the globe. Although animal studies have shown the potential neurotoxicity of PFCs, there are few epidemiological studies regarding neurological effects of PFCs in humans, and those studies have had inconclusive results. In this study, we conducted a hospital-based prospective birth cohort study between 2002 and 2005 (n = 514) to examine the associations between prenatal perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) exposures and the neurodevelopment of infants at 6 (n = 173) and 18 (n = 133) months of age. Using the second edition of the Bayley Scales of Infant Development (BSID II), the Mental and Psychomotor Developmental Indices (MDI and PDI, respectively) were assessed. PFOS and PFOA were measured in maternal serum samples by liquid chromatography-tandem mass spectrometry. After controlling for confounders, prenatal PFOA concentrations were associated with the MDI of female (but not male) infants at 6 months of age (beta = -0.296; 95% confidence interval (CI): -11.96, -0.682). Furthermore, females born to mothers with prenatal concentrations of PFOA in the fourth quartile had MDI scores -5.05 (95% CI: -10.66 to 0.55) lower than females born to mothers with concentrations of PFOA in the first quartile (p for trend = 0.045). However, PFOA concentrations were not significantly associated with neurodevelopmental indices at 18 months of age. In addition, we did not observe any significant association between PFOS concentrations and neurodevelopmental outcomes in early infancy. In conclusion, our results suggest that prenatal PFOA exposure may affect female mental scales of neurodevelopment at 6 months of age. Further studies with larger sample sizes and longer observation periods are required to clarify sex difference of the neurodevelopmental effects. (C) 2015 Elsevier B.V. All rights reserved.