Supplemental choline during the periweaning period protects against trace conditioning impairments attributable to post-training ethanol exposure in adolescent rats.
Supplemental choline during the periweaning period protects against trace conditioning impairments attributable to post-training ethanol exposure in adolescent rats.
复制标题
围断奶期间补充胆碱可防止青春期大鼠因训练后乙醇暴露而造成的微量条件反射损伤。
DOI：
10.1037/a0028878
复制
发表时间：
2012
影响因子：
1.9
通讯作者：
Hunt,PamelaS
中科院分区：
文献类型：
--
作者：
Hunt,PamelaS
在发育的早期阶段补充胆碱可以长期改善记忆功能。此外，出生前或出生后的胆碱已被证明可以防止早期酒精暴露的一些不良影响。本实验研究是否补充胆碱给予大鼠将保护对微量恐惧条件反射训练后酒精管理的影响。青少年大鼠训练后暴露于酒精会导致这种海马依赖性任务的表现不佳，尽管延迟条件反射不受影响。在这里，大鼠在出生后第15-26天（PD）每天皮下注射生理盐水或氯化胆碱。在PD时，对30名受试者进行微量恐惧条件反射程序的培训。在接下来的3天中，向动物施用2.5g/kg乙醇或水对照，并在PD 34时测量条件刺激（CS）引起的冻结。结果表明，训练后酒精破坏了微量条件反射的表达，PD 15-26补充胆碱对这种影响具有保护作用。也就是说，胆碱治疗的动物，随后给予训练后的乙醇表现以及动物没有给予乙醇。这些结果表明，在围断奶期补充胆碱保护对乙醇诱导的障碍，在一个依赖于大脑的学习任务。这些发现有助于越来越多的文献表明，在大脑发育的关键时期，给予额外饮食胆碱的受试者的学习和记忆得到了改善。（PsycInfo数据库记录（c）2020阿帕，保留所有权利）
Supplemental choline during early stages of development can result in long-lasting improvements to memory function. In addition, pre-or postnatal choline has been shown to be protective against some of the adverse effects of early alcohol exposure. The present experiment examined whether supplemental choline given to rats would protect against the effects of posttraining alcohol administration on trace fear conditioning. Posttraining alcohol exposure in adolescent rats results in poor performance in this hippocampus-dependent task, although delay conditioning is unaffected. Here, rats were given an sc injection of either saline or choline chloride daily on postnatal days (PD) 15–26. On PD 30 subjects were trained in a trace fear conditioning procedure. For the next 3 days animals were administered 2.5 g/kg ethanol or water control, and conditional stimulus (CS)-elicited freezing was measured on PD 34. Results indicated that posttraining alcohol disrupted the expression of trace conditioning and that supplemental choline on PD 15–26 was protective against this effect. That is, choline-treated animals subsequently given posttraining ethanol performed as well as animals not given ethanol. These results indicate that supplemental choline given during the periweaning period protects against ethanol-induced impairments in a hippocampus-dependent learning task. Findings contribute to the growing literature showing improvements in learning and memory in subjects given extra dietary choline during critical periods of brain development.(PsycInfo Database Record (c) 2020 APA, all rights reserved)