Multilineage hematopoietic reconstitution of supralethally irradiated rats by syngeneic whole organ transplantation - With particular reference to the liver
Multilineage hematopoietic reconstitution of supralethally irradiated rats by syngeneic whole organ transplantation - With particular reference to the liver
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DOI：
10.1097/00007890-199601150-00001
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发表时间：
1996-01-15
期刊：
影响因子：
6.2
通讯作者：
Demetris, AJ
中科院分区：
文献类型：
--
作者：
Murase, N;Starzl, TE;Demetris, AJ
The migration of multilineage “passenger leukocytes” from transplanted organs and their ubiquitous survival in successfully treated human recipients for as long as 30 years (microchimerism) has been postulated to be an essential condition for organ allograft acceptance and the explanation for a number of previously enigmatic posttransplant events (1, 2). Following organ revascularization in either humans or rodents, donor leukocytes appear in large numbers in the recipient blood but usually diminish over a few days to a level undetectable with flow cytometry (2-5). We have construed the persistence of donor cells thereafter as prima facie evidence of the presence of hematopoietic stem and precursor cells (1, 2, 6).When the blood compartment is serially sampled in long-surviving human organ recipients, the levels of donor cells fluctuate (7), presumably reflecting cyclic activity of these stem cells. Taniguchi et al.(8) showed that primitive CD45+ cells purified from adult mouse livers unfailingly reconstituted all hematolymphopoietic lineages in supralethally irradiated adult mouse recipients. We present here direct evidence that supralethally irradiated adult rats can be consistently rescued by syngeneic liver transplantation, and that heart transplantation has a less dramatic but significant therapeutic effect.
