HLA-D region genes associated with autoantibody responses to histidyl-transfer RNA synthetase (Jo-1) and other translation-related factors in myositis.
HLA-D region genes associated with autoantibody responses to histidyl-transfer RNA synthetase (Jo-1) and other translation-related factors in myositis.
复制标题
HLA-D 区域基因与肌炎中组氨酰转移 RNA 合成酶 (Jo-1) 和其他翻译相关因子的自身抗体反应相关。
DOI：
10.1002/art.1780330826
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发表时间：
1990
影响因子：
--
通讯作者：
Arnett,FC
中科院分区：
文献类型：
--
作者：
Goldstein,R;Duvic,M;Targoff,IN;Reichlin,M;McMenemy,AM;Reveille,JD;Warner,NB;Pollack,MS;Arnett,FC
肌炎与HLA-B8和DR 3相关，特别是在患有多发性肌炎和血清抗Jo-1抗体的白色患者中。通过使用HLA-DR β、DQβ和DQα探针的Southern印迹法，研究了28例肌炎患者和血清翻译相关自身抗体抗Jo-1、抗PL-7、抗PL-12、抗KJ和抗SRP的HLA II类特异性。白色肌炎患者中HLA-DR 3（DRw 17）与抗Jo-1抗体的相关性得到证实（P= 0.003，相对风险8.9）。然而，HLA-DRw 52单倍型，无论亚型如何，都存在于所有血清抗Jo-1和其他翻译相关自身抗体的白色和黑人患者中。此外，1名抗Jo 1阳性患者具有HLA-DRw 8，这是一种HLA-DRw 52单倍型，其DRβ3基因已部分缺失。所有患者均无HLA-DQ特异性或等位基因。具有HLA-DRw 52特异性的HLA-DR 3、DR 5、DRw 6和DRw 8单倍型在氨基酸位置9-13处的DRβ1第一高变区中共享最大同源性。因此，该DRβ1区域似乎是炎性肌炎中翻译相关自身免疫反应的最可能的候选“表位”。
Myositis has been associated with HLA‐B8 and DR3, especially in white patients with polymyositis and serum anti‐Jo‐1 antibodies. Twenty‐eight patients with myositis and serum translation‐related autoantibodies anti‐Jo‐1, anti‐PL‐7, anti‐PL‐12, anti‐KJ, and anti‐SRP were studied for HLA class II specificities by Southern blotting with HLA‐DRβ, DQβ, and DQα probes. The association of HLA‐DR3 (DRw17) with anti‐Jo‐1 antibodies in white myositis patients was confirmed (P= 0.003, relative risk 8.9). However, HLA‐DRw52 haplotypes, regardless of subtype, were present in all of the white and black patients with serum anti‐Jo‐1 and other translation‐related autoantibodies. Moreover, one anti‐Jo‐1 positive patient had HLA‐DRw8, an HLA‐DRw52 haplotype on which the DRβ3 gene has been partially deleted. No HLA‐DQ specificity or allele was common to all patients. The HLA‐DR3, DR5, DRw6, and DRw8 haplotypes, which bear the HLA‐DRw52 specificity, share the most homology in the DRβ1 first hypervariable region at amino acid positions 9–13. Thus, this DRβ1 region appears to be the most likely candidate “epitope” for translation‐related autoimmune responses in inflammatory myositis.