Second-line anticonvulsant treatment of neonatal seizures - A video-EEG monitoring study
Second-line anticonvulsant treatment of neonatal seizures - A video-EEG monitoring study
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DOI：
10.1212/01.wnl.0000106944.59990.e6
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发表时间：
2004-02-10
期刊：
影响因子：
9.9
通讯作者：
Binnie, CD
中科院分区：
文献类型：
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作者：
Boylan, GB;Rennie, JM;Binnie, CD
作者进行了一项新生儿二线抗惊厥治疗的随机试验。使用连续视频EEG评估对治疗的反应，因为已知新生儿癫痫发作的临床诊断不可靠。在27例EEG证实癫痫发作的新生儿中，5例因违反方案而被排除，11例对40 mg/kg剂量的苯巴比妥作为一线治疗有反应。五个新生儿中有三个接受了木质素治疗。6名新生儿接受苯二氮卓类药物作为二线治疗：无应答，神经发育结局较差。
The authors conducted a randomized trial of second-line anticonvulsant treatments for neonates. The response to treatment was assessed using continuous video-EEG)because the clinical diagnosis of seizure in neonates is known to be unreliable. Of 27 neonates with EEG-confirmed seizures, 5 were excluded because of protocol violations, and 11 responded to phenobarbitone in a dose of 40 mg/kg as first line. Three of five neonates treated with lignocaine responded. Six neonates were treated with benzodiazepines as second line: None responded, and their neurodevelopmental outcome was poor.