CD45 PROTEIN-TYROSINE-PHOSPHATASE - DETERMINATION OF MINIMAL PEPTIDE LENGTH FOR SUBSTRATE RECOGNITION AND SYNTHESIS OF SOME TYROSINE-BASED ELECTROPHILES AS POTENTIAL ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS
CD45 PROTEIN-TYROSINE-PHOSPHATASE - DETERMINATION OF MINIMAL PEPTIDE LENGTH FOR SUBSTRATE RECOGNITION AND SYNTHESIS OF SOME TYROSINE-BASED ELECTROPHILES AS POTENTIAL ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS
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DOI：
10.1016/0960-894x(95)00034-q
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发表时间：
1995-02-16
影响因子：
2.7
通讯作者：
HIGGINS, TJ
中科院分区：
文献类型：
--
作者：
BOBKO, M;WOLFE, HR;HIGGINS, TJ
以fyn PTK为模板，制备了一系列长度为1-14个氨基酸的磷酸肽1-11。1-11的动力学评价表明，CD 45不具有强烈的偏好，其N-或C-末端氨基酸和延长的磷酸肽不需要有效的底物周转。
Using fyn PTK as a template, a series of phosphopeptides 1-11 spanning in length from 1-14 amino acids was prepared. Kinetic evaluation of 1-11 suggest that CD45 does not have a strong preference for its N- or C-terminal amino acids and that extended phosphopeptides are not required for efficient substrate turnover.