Mood disorders in HIV infection: prevalence and risk factors in a nonepicenter of the AIDS epidemic.
Mood disorders in HIV infection: prevalence and risk factors in a nonepicenter of the AIDS epidemic.
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HIV 感染者的情绪障碍：艾滋病流行非中心地区的患病率和危险因素。
DOI：
10.1176/ajp.151.2.233
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Evans,DL
中科院分区：
文献类型：
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作者：
Perkins,DO;Stern,RA;Golden,RN;Murphy,C;Naftolowitz,D;Evans,DL
作者研究了生活在艾滋病毒低流行地区的无症状艾滋病毒感染者和未感染者的终身、初始横断面和6个月随访的情绪障碍患病率。他们还确定了目前的抑郁症和潜在的抑郁症的危险factors.MethodSubjects包括98无症状的HIV感染者和71未感染的同性恋男性之间的关系。受试者进行了广泛的临床，精神，神经心理学，和实验室evaluations.ResultsSimilarproportions的HIV感染和未感染的受试者报告的一生（29%和45%，分别），初始电流（8%和3%），和6个月的随访（9%和11%）的历史，严重抑郁症。焦虑症不太常见，HIV感染者和未感染者报告终生（分别为7%和13%），初始电流（3%和7%）和6个月随访（2%和5%）焦虑症病史的比例相似。艾滋病毒感染者和未感染者的情绪症状严重程度没有差异。目前的抑郁症在首次访问显着相关的抑郁症的终身史，但不与神经心理功能或维生素B12 level.ConclusionsThese研究结果是在以前的研究与艾滋病毒的高患病率的地区。然而，与一般人群研究相比，情绪障碍受试者的比例很高。感染和未感染艾滋病毒的同性恋男子都可能有患重度抑郁症的高风险，特别是如果他们有抑郁症病史。此外，在艾滋病毒感染的无症状阶段，严重抑郁症似乎并不继发于艾滋病毒中枢神经系统的影响或维生素B12水平低。
ObjectiveThe authors studied the lifetime, initial cross-sectional, and 6-month follow-up prevalence of mood disorders in asymptomatic HIV-infected and uninfected homosexual men who lived in an area with a low prevalence of HIV. They also determined the relationship between current major depression and potential depression risk factors.MethodSubjects included 98 asymptomatic HIV-infected and 71 uninfected homosexual men. Subjects underwent extensive clinical, psychiatric, neuropsychological, and laboratory evaluations.ResultsSimilar proportions of HIV-infected and uninfected subjects reported a lifetime (29% and 45%, respectively), an initial current (8% and 3%), and a 6-month follow-up (9% and 11%) history of major depressive disorder. Anxiety disorders were less common, with similar proportions of HIV-infected and uninfected subjects reporting a lifetime (7% and 13%, respectively), an initial current (3% and 7%), and a 6-month follow-up (2% and 5%) history of anxiety disorders. There were no differences in the severity of mood symptoms between HIV-infected and uninfected subjects. Current major depression at initial visit was significantly associated with lifetime history of major depression but not with neuropsychological function or vitamin B12 level.ConclusionsThese findings are in agreement with previous studies of areas with a high prevalence of HIV. However, the proportion of subjects with mood disorders is high compared with general population studies. Both HIV-infected and uninfected homosexual men may be at high risk for major depression, especially if they have a past history of depression. Moreover, in the asymptomatic stage of HIV infection, major depression does not appear to be secondary to HIV central nervous system effects or low vitamin B12 levels.