Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method
Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method
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DOI：
10.5830/cvja-2016-047
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发表时间：
2017-01-01
影响因子：
0.7
通讯作者：
Namugowa, A.
中科院分区：
文献类型：
--
作者：
Meeme, A.;Buga, G. A. B.;Namugowa, A.
目的：EndoPAT方法已被用作评估几个非妊娠人群内皮功能的非侵入性方法。我们研究了其可能的用途在评估内皮功能障碍先兆子痫。方法：215名参与者被招募和分组为先兆子痫的情况下（105）和血压正常的对照组（110）。结果：子痫前期组反应性充血指数显著低于正常血压组（P <0.05），子痫前期组反应性充血指数显著低于正常血压组（P < 0.05），子痫前期组反应性充血指数显著低于正常血压组（P < 0.05）。另一方面，与正常血压组相比，先兆子痫组中的增强指数显著更高（p < 0.0001）。
Objectives: The EndoPAT method has been used as a non-invasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia.Methods: Two hundred and fifteen participants were recruited and grouped as pre-eclamptic cases (105) and normotensive controls (110). Endothelial function and arterial stiffness were measured as reactive hyperaemia index and augmentation index, respectively, using the EndoPAT 2000 machine.Results: The reactive hyperaemia index was significantly lower in the pre-eclamptic group compared to the normotensive group (p < 0.05). Augmentation index on the other hand was significantly higher in the pre-eclamptic group compared to the normotensive group (p < 0.0001).Conclusion: The EndoPAT method demonstrates endothelial dysfunction and arterial stiffness in pre-eclampsia.