CGRP- and cholinergic-containing fibers project to guinea pig outer hair cells
CGRP- and cholinergic-containing fibers project to guinea pig outer hair cells
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DOI：
10.1016/s0378-5955(02)00305-2
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发表时间：
2002-10-01
期刊：
影响因子：
2.8
通讯作者：
Luebke, AE
中科院分区：
文献类型：
--
作者：
Cabanillas, LA;Luebke, AE
MU33，降钙素基因相关肽（CGRP）的抗体，被用来调查CGRP的神经纤维末梢的大小，相比，乙酰胆碱酯酶（AChE）的神经纤维末梢的外毛细胞（OHC）。结果表明，CGRP的神经纤维免疫反应性模仿AChE纤维OHC染色模式整个耳蜗表明CGRP可以作为内侧传出（接触主要OHC）和作为外侧传出（接触主要内毛细胞传入）神经递质。(C)2002 Elsevier Science B.V.保留所有权利。
MU33, an antibody to calcitonin gene-related peptide (CGRP), was used to investigate the magnitude of CGRP-containing nerve fiber endings, compared to acetylcholinesterase (AChE)-containing nerve fiber endings on outer hair cells (OHCs). Results showed that CGRP-containing nerve fiber immunoreactivity mimicked the AChE fiber OHC staining pattern across the cochlea suggesting that CGRP can function as both a medial efferent (contacting primarily OHCs) and as a lateral efferent (contacting primarily inner hair cell afferents) neurotransmitter. (C) 2002 Elsevier Science B.V. All rights reserved.