Effect of a treat-to-target intervention of cardiovascular risk factors on subclinical and clinical atherosclerosis in rheumatoid arthritis: a randomised clinical trial
Effect of a treat-to-target intervention of cardiovascular risk factors on subclinical and clinical atherosclerosis in rheumatoid arthritis: a randomised clinical trial
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DOI：
10.1136/annrheumdis-2018-214075
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发表时间：
2019-03-01
影响因子：
27.4
通讯作者：
Cabezas, Manuel Castro
中科院分区：
文献类型：
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作者：
Burggraaf, Benjamin;van Breukelen-van der Stoep, Deborah F.;Cabezas, Manuel Castro
背景类风湿性关节炎（RA）患者发生心血管疾病（CVD）的风险增加。尚未发表关于CVD危险因素的长期干预试验，关于控制RA传统危险因素的有效性的辩论正在进行中。我们的目的是评估一种达标治疗方法与常规治疗方法对RA患者传统CVD危险因素的影响。
Background Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease (CVD). No long-term intervention trials on CVD risk factors have been published, and a debate on the efficacy of controlling traditional risk factors in RA is ongoing. We aimed to evaluate a treat-to-target approach versus usual care regarding traditional CVD risk factors in patients with RA.Methods In this open-label, randomised controlled trial, patients with RA aged