Preserved semantic access in global amnesia and hippocampal damage
Preserved semantic access in global amnesia and hippocampal damage
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DOI：
10.1076/clin.15.4.508.1889
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发表时间：
2001-01-01
影响因子：
3.9
通讯作者：
Bugiani, O
中科院分区：
文献类型：
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作者：
Giovagnoli, AR;Erbetta, A;Bugiani, O
C. B.右利手的33岁男性，急性心脏传导阻滞后出现顺行性遗忘。认知能力正常，但长期情景记忆严重受损。对语义信息的访问得到充分保留。磁共振显示双侧海马高信号强度和明显的体积损失;左右海马旁回、枕颞外侧回、颞下回和颞外侧皮质正常。这个病例强调了与海马损伤相关的全面遗忘症并不影响语义记忆。虽然海马体在提取上下文相关信息方面很重要，但它在提取语义内容方面的作用并不那么重要。海马周围的皮质区和颞叶外侧区可能引导语义信息的回忆。
C.B., a right-handed 33-year-old man, presented with anterograde amnesia after acute heart block. Cognitive abilities were normal except for serious impairment of long-term episodic memory. The access to semantic information was fully preserved. Magnetic resonance showed high signal intensity and marked volume loss in the hippocampus bilaterally; the left and right parahippocampal gyrus, lateral occipito-temporal gyrus, inferior temporal gyrus, and lateral temporal cortex were normal. This case underlines that global amnesia associated with hippocampal damage does not affect semantic memory. Although the hippocampus is important in retrieving context-linked information, its role is not so crucial in retrieving semantic contents. Cortical areas surrounding the hippocampus and lateral temporal areas might guide the recall of semantic information.