Global disparities in SARS-CoV-2 genomic surveillance.
Global disparities in SARS-CoV-2 genomic surveillance.
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DOI：
10.1038/s41467-022-33713-y
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发表时间：
2022-11-16
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
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作者：
基因组测序对于追踪SARS-CoV-2的进化和传播，优化分子测试，治疗，疫苗以及指导公共卫生反应至关重要。为了调查全球SARS-CoV-2基因组监测，我们使用GISAID共享的序列来估计测序强度和周转时间对189个国家变异检测的影响。在大流行的头两年，78%的高收入国家的COVID-19病例测序率>0.5%，而42%的低收入和中等收入国家达到了这一水平。高收入国家大约25%的基因组在21天内提交，低收入和中等收入国家5%的基因组也是如此。我们发现，测序约0.5%的病例，周转时间<21天，可以为SARS-CoV-2基因组监测提供基准。社会经济不平等损害了全球大流行病防备工作，必须努力支持中低收入国家提高其当地测序能力。在这项研究中，作者提供了SARS-CoV-2基因组测序的全球概述，并估计了测序病例的比例和基因组上传的时间。报告指出了差距，并强调需要加强中低收入国家的监测。
Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments, vaccines, and guide public health responses. To investigate the global SARS-CoV-2 genomic surveillance, we used sequences shared via GISAID to estimate the impact of sequencing intensity and turnaround times on variant detection in 189 countries. In the first two years of the pandemic, 78% of high-income countries sequenced >0.5% of their COVID-19 cases, while 42% of low- and middle-income countries reached that mark. Around 25% of the genomes from high income countries were submitted within 21 days, a pattern observed in 5% of the genomes from low- and middle-income countries. We found that sequencing around 0.5% of the cases, with a turnaround time <21 days, could provide a benchmark for SARS-CoV-2 genomic surveillance. Socioeconomic inequalities undermine the global pandemic preparedness, and efforts must be made to support low- and middle-income countries improve their local sequencing capacity. In this study, the authors provide a global overview of SARS-CoV-2 genome sequencing, and estimate the proportion of cases sequenced and time to genome upload. They identify disparities and highlight the need to strengthen surveillance in lower and middle income countries.
影响因子：
4.7
作者：
Ye S;Zhang Y;Zhao X;Yu Z;Song Y;Tan Z;Tang Y;Chen S;Wang M;Ling H
通讯作者：
Ling H