Fingers as a Marker of Prenatal Androgen Exposure
Fingers as a Marker of Prenatal Androgen Exposure
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DOI：
10.1210/en.2009-0774
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发表时间：
2009-11-01
期刊：
影响因子：
4.8
通讯作者：
Moffat, Scott
中科院分区：
文献类型：
--
作者：
Berenbaum, Sheri A.;Bryk, Kristina Korman;Moffat, Scott
对心理和生理特征中性别相关变化的生物学底物的兴趣导致了对可以在出生后测量的产前激素暴露的生物标志物的搜索。人们对手指比（第二和第四手指的相对长度（2D：4D））特别感兴趣，但其作为产前雄激素测量的有效性尚未确定。我们报告了2D：4D作为早期雄激素暴露的生物标志物的价值的最强评估。具有46，XY染色体组型但由于完全雄激素不敏感综合征而没有有效产前雄激素暴露的个体的指数比呈女性化：它们高于典型男性，但与典型女性相似。然而，这种影响是适度的大小，有相当大的组内变异性和组间重叠，表明手指比不是一个很好的标记产前雄激素暴露的个体差异。（内分泌学150：5119-5124，2009）
Interest in biological substrates of sex-related variations in psychological and physiological characteristics has led to a search for biomarkers of prenatal hormone exposure that can be measured postnatally. There has been particular interest in digit ratio, the relative lengths of the second and fourth fingers (2D:4D), but its validity as a measure of prenatal androgen has not been established. We report the strongest evaluation of the value of 2D:4D as a biomarker for early androgen exposure. Individuals with 46,XY karyotype but no effective prenatal androgen exposure due to complete androgen insensitivity syndrome had digit ratios that were feminized: they were higher than those of typical men and similar to those of typical women. Nevertheless, the effect was modest in size, and there was considerable within-group variability and between-group overlap, indicating that digit ratio is not a good marker of individual differences in prenatal androgen exposure. (Endocrinology 150: 5119-5124, 2009)