WISP-2: a serum-inducible gene differentially expressed in human normal breast epithelial cells and in MCF-7 breast tumor cells.
WISP-2: a serum-inducible gene differentially expressed in human normal breast epithelial cells and in MCF-7 breast tumor cells.
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WISP-2：一种血清诱导基因，在人正常乳腺上皮细胞和 MCF-7 乳腺肿瘤细胞中差异表达。
DOI：
10.1006/bbrc.2001.4584
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发表时间：
2001
影响因子：
3.1
通讯作者：
Banerjee,SK
中科院分区：
文献类型：
--
作者：
Zoubine,MN;Banerjee,S;Saxena,NK;Campbell,DR;Banerjee,SK
WISP-2 是一种 Wnt-1 诱导的信号蛋白，被鉴定为 CCN 生长因子家族的成员。人们怀疑该分子在肿瘤发生过程中的作用，但尚未得到证实。在这里，我们表明，WISP-2 表达在未转化的人乳腺上皮细胞中检测不到或最低限度地检测到，但在 MCF-7 细胞中过表达。 MCF-7 细胞中 WISP-2 的表达受血清调节，并与血清诱导的 MCF-7 肿瘤细胞增殖相关，表明 WISP-2 具有血清反应性，可能是肿瘤细胞增殖的正调节因子。
WISP-2 is a Wnt-1-induced signaling protein identified as a member of CCN growth factor family. A role for this molecule during tumorigenesis is suspected but remains unproven. Here we show that WISP-2 expression was undetectable, or minimally detectable, in nontransformed human mammary epithelial cells, but was overexpressed in MCF-7 cells. Expression of WISP-2 in MCF-7 cells was modulated by serum and correlated with the serum-induced MCF-7 tumor cell proliferation, suggesting that WISP-2 is serum responsive and may be a positive regulator of tumor cell proliferation.