Placental structure, function and drug transfer
Placental structure, function and drug transfer
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DOI：
10.1093/bjaceaccp/mku013
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发表时间：
2015-04-01
期刊：
影响因子：
1.6
通讯作者：
Campbell, Jeremy P.
中科院分区：
文献类型：
--
作者：
Griffiths, Sarah K.;Campbell, Jeremy P.
在20世纪50年代末和60年代初，沙利度胺引起的一系列毁灭性的出生缺陷提高了人们对胎盘作为药物转移屏障的不完美状态的认识。随后的研究试图阐明药物经胎盘转运的确切性质和机制。人们对有意使用母亲给药的药物也越来越感兴趣，这些药物旨在穿过胎盘，对胎儿提供治疗效果。本文就胎盘的结构和主要功能作一综述。它还总结了我们目前对胎盘药物转移的理解，特别是用于妊娠麻醉和镇痛的药物。
In the late 1950s and early 1960s, the devastating series of thalidomide-induced birth defects raised awareness of the imperfect state of the placenta as a barrier to drug transfer. Subsequent research has sought to elucidate the precise nature and mechanisms of transplacental drug passage. There has also been increasing interest in the deliberate use of maternally administered drugs designed to cross the placenta and provide therapeutic effects on the fetus. This article reviews the structure and key functions of the placenta. It also summarizes our current understanding of placental drug transfer, particularly of drugs used for anaesthesia and analgesia in pregnancy.