Cigarette smoking, alcohol consumption and subsequent gastric cancer risk by subsite and histologic type
Cigarette smoking, alcohol consumption and subsequent gastric cancer risk by subsite and histologic type
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DOI：
10.1002/ijc.10649
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发表时间：
2002-10-20
影响因子：
6.4
通讯作者：
Tsugane, S
中科院分区：
文献类型：
--
作者：
Sasazuki, S;Sasaki, S;Tsugane, S
吸烟或饮酒对胃癌风险的影响尚未明确。考虑到胃癌的解剖亚位和组织学类型，我们研究了这种关系。共有19657名男性（基线年龄40-59岁），他们回答了基线问卷，当时没有报告严重疾病。，从1990年1月到1999年12月，随访了10年。293例男性经组织学检查证实为胃癌。吸烟与远端胃癌分化类型的风险增加有关；与从不吸烟的组相比，过去吸烟者和现在吸烟者胃癌的调整率比（rr）分别为2.0 （95% Cl 1.1-3.7）和2.1 （95% Cl 1.2-3.6）。没有观察到吸烟与未分化型远端胃癌风险之间的关联，除了与贲门癌有暗示的关联。就饮酒而言，只有在所有组织学类型的贲门癌中，风险才会升高，尽管这种关系没有达到显著性。在每周饮酒1次以上的人群中，酒精摄入量为2.7 ~ 161.0、162.0 ~ 322.0和322.5+ g/周与饮酒0 ~ 3次/月人群的相对危险度分别为2.5 （95% Cl 0.7 ~ 9.5）、3.3（0.9 ~ 11.6）和3.0 (0.8 ~ 11.1)（p（趋势）= 0.66）。总之，我们的研究结果证实吸烟与分化型胃癌有关。需要更多病例的进一步研究来发现吸烟或饮酒与贲门癌之间的正相关关系。(C) 2002 Wiley-Liss, Inc。
The effect of cigarette smoking or alcohol consumption on the risk of gastric cancer has not been clarified. We investigated this relationship, considering the anatomic subsite and histologic type of gastric cancer. A total of 19,657 men (aged 40-59 years at baseline), who responded to the baseline questionnaire and reported no serious illness at that time., were followed for 10 years, from January 1990 to December 1999. Gastric cancer was confirmed histologically in 293 men. Smoking was associated with an increased risk of the differentiated type of distal gastric cancer; compared to the group who never smoked, the adjusted rate ratios (RRs) of gastric cancer for past and current smokers were 2.0 (95% Cl 1.1-3.7) and 2.1 (95% Cl 1.2-3.6), respectively. No association was observed between cigarette smoking and risk of the undifferentiated type of distal gastric cancer except for a suggestive association with cardia cancer. For alcohol consumption, elevated risk was suggested only for cardia cancer of all histologic types, though the relationship failed to reach significance. Among those who drank alcohol at least once per week, RRs for ethanol intake of 2.7-161.0, 162.0-322.0 and 322.5+ g/week compared to those who drank 0-3 times/month were 2.5 (95% Cl 0.7-9.5), 3.3 (0.9-11.6) and 3.0 (0.8-11.1), respectively (p(trend) = 0.66). In conclusion, our results confirm that smoking is related to gastric cancer of the differentiated type. Further studies with more cases are needed to detect a positive association between cigarette smoking or alcohol consumption and cardia cancer. (C) 2002 Wiley-Liss, Inc.