Skin diseases associated with hepatitis C virus infection
Skin diseases associated with hepatitis C virus infection
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与丙型肝炎病毒感染相关的皮肤病
DOI：
10.1111/j.1468-3083.1998.tb00922.x
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发表时间：
1998
影响因子：
9.2
通讯作者：
S. Hadziyannis
中科院分区：
文献类型：
--
作者：
S. Hadziyannis
丙型肝炎病毒 (HCV) 是一种通过明显和不明显的肠胃外程序传播的血源性病原体，是世界范围内肝病的常见原因。急性和慢性丙型肝炎病毒感染都可能影响肝脏以及各种非肝组织。已认识到许多肝外疾病与HCV感染有关，其中皮肤病占核心部分。皮肤坏死性血管炎、混合性冷球蛋白血症、迟发性皮肤卟啉症和扁平苔藓是常与 HCV 感染相关的主要皮肤病，但其他皮肤病，如 Adamantiadis-BehQet 综合征、多形性红斑和结节性红斑、软斑、荨麻疹和瘙痒也可能与 HCV 感染有关。 丙型肝炎。需要进一步研究来确定或反驳丙型肝炎病毒在这些疾病中的致病作用。皮肤表现也是与 HCV 感染相关的其他肝外疾病临床表现的一部分，例如甲状腺功能障碍和 HCV 相关血小板减少症。干扰素 α (a-IFN) 治疗皮肤病的反应是不可预测的，一些患者病情有所改善，另一些患者保持稳定，另一些患者病情恶化。
Hepatitis C virus (HCV) is a bloodborne agent transmitted by apparent and inapparent parenteral procedures representing a frequent cause of liver disease world‐wide. Both acute and chronic HCV infection may affect the liver as well as various non‐hepatic tissues. Numerous extrahepatic disorders have been recognised in association with HCV infection among which dermatological diseases occupy a central part. Cutaneous necrotising vasculitis, mixed cryoglobulinemia, porphyria cutanea tarda and lichen planus are the major skin diseases frequently associated with HCV infection, but other skin disorders, such as Adamantiadis‐BehQet syndrome, erythema multiforme and nodosum, malacoplakia, urticaria and pruritus, may also be linked to hepatitis C. Further studies are necessary to establish or refute an aetiopathogenetic role of HCV in these conditions. Skin manifestations are also part of the clinical picture of other extrahepatic disorders associated with HCV infection, such as thyroid dysfunction and HCV‐related thrombocytopenia. The response to interferon alpha (a‐IFN) therapy in skin diseases is unpredictable with some patients ameliorating, others remaining stationary and others deteriorating.
竹冈克也肖像（下）
DOI：
--
发表时间：
2008
期刊：
史淵 145
影响因子：
--
作者：
TOKUNAGA;Yosuke;山口 輝臣
通讯作者：
山口 輝臣