Obstructive sleep apnea and carotid-artery intima-media thickness
Obstructive sleep apnea and carotid-artery intima-media thickness
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DOI：
10.1093/sleep/27.1.129
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发表时间：
2004-02-01
期刊：
影响因子：
5.6
通讯作者：
Kimura, H
中科院分区：
文献类型：
--
作者：
Suzuki, T;Nakano, H;Kimura, H
研究目的：探讨超声测量的颈动脉内膜厚度(IMT)是否与阻塞性睡眠呼吸暂停(OSA)的严重程度有关。设计：横断面研究。地点：日本一家综合性医院的睡眠实验室。患者：共有167例患者到医院睡眠实验室进行OSA的筛查或治疗。他们没有慢性阻塞性肺疾病、脑血管疾病或心血管疾病的病史。干预：无。测量和结果：多导睡眠图诊断阻塞性睡眠呼吸暂停。超声测量颈动脉内膜厚度，并调查已知的动脉粥样硬化危险因素(年龄、肥胖、高脂血症、高血压、糖尿病和胰岛素抵抗)。在调整混杂因素后，进行多元回归分析以评估IMT与OSA严重程度之间的相关性。这一分析表明，在调整了可能促进动脉粥样硬化的混杂因素后，呼吸暂停低通气指数、血氧饱和度低于90%的持续时间和平均最低氧饱和度与IMT显著相关。结论：OSA相关低氧血症的严重程度与动脉粥样硬化独立相关，OSA相关低氧血症的严重程度比梗阻事件的发生频率更重要。
Study Objectives: We investigated whether the carotid-artery intimamedia thickness (IMT) measured by ultrasonography, which is regarded as an indicator of atherosclerosis, was associated with the severity of obstructive sleep apnea (OSA).Design: Cross-sectional study.Setting: A sleep laboratory in a general hospital in Japan.Patients: A total of 167 patients referred to the sleep laboratory of our hospital for screening or treatment of OSA were investigated. They had no history of chronic obstructive pulmonary disease, cerebrovascular disease, or cardiovascular disease. Interventions: NA.Measurements and Results: Obstructive sleep apnea was diagnosed by polysomnography. Carotid-artery IMT was measured by ultrasonography, and known risk factors for atherosclerosis (age, obesity, hyperlipidemia, hypertension, diabetes mellitus, and insulin resistance) were also investigated. Multiple regression analysis was performed to assess the association between IMT and the severity of OSA, after adjusting for confounding factors. This analysis revealed that the apnea-hypopnea index, the duration of an oxygen saturation below 90%, and the mean nadir oxygen saturation were significantly associated with the IMT after adjustment for confounding factors that could promote atherosclerosis. Moreover, OSA-related hypoxemia was associated with the IMT independently of the apnea-hypopnea index.Conclusions: Our results demonstrated that the severity of OSA is independently related to atherosclerosis and that the severity of OSA-related hypoxemia is more important than the frequency of obstructive events.