The Boosting Potential of Bacteria in Cancer Immunotherapy.
The Boosting Potential of Bacteria in Cancer Immunotherapy.
复制标题
细菌在癌症免疫治疗中的增强潜力。
DOI：
10.1016/j.molmed.2017.05.008
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发表时间：
2017
影响因子：
13.6
通讯作者：
Wainwright,DerekA
中科院分区：
文献类型：
--
作者：
Binder,DavidC;Wainwright,DerekA
鼠伤寒沙门氏菌被设计用来表达鞭毛蛋白B，最近通过TLR依赖的机制展示了前所未有的肿瘤控制。在这里，我们回顾了新的观察结果，支持利用修饰细菌来增强抗肿瘤免疫的潜力。我们还讨论了这些发现对临床应用的影响，包括免疫检查点阻断疗法。
SalmonellaTyphimurium, engineered to express flagellin B, recently demonstrated unprecedented tumor control through a TLR-dependent mechanism. Here, we review new observations that support the potential of utilizing modified bacteria to enhance antitumor immunity. We also discuss the implications of these findings for clinical applications, including immune checkpoint blockade therapies.