THE EFFECTS OF 6-OHDA-INDUCED DOPAMINE DEPLETIONS IN THE VENTRAL OR DORSAL STRIATUM ON MATERNAL AND SEXUAL-BEHAVIOR IN THE FEMALE RAT
THE EFFECTS OF 6-OHDA-INDUCED DOPAMINE DEPLETIONS IN THE VENTRAL OR DORSAL STRIATUM ON MATERNAL AND SEXUAL-BEHAVIOR IN THE FEMALE RAT
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DOI：
10.1016/0091-3057(91)90399-m
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发表时间：
1991-05-01
影响因子：
3.6
通讯作者：
SVENSSON, K
中科院分区：
文献类型：
--
作者：
HANSEN, S;HARTHON, C;SVENSSON, K
在雌性大鼠中检查腹侧或背侧纹状体中多巴胺消耗6-OHDA输注对母性和性行为的影响。与假手术对照组一样，在腹侧纹状体接受6-OHDA的哺乳期大鼠建立了良好的巢穴，喂养婴儿，并表现出对陌生入侵者的母性攻击。相比之下，损伤的女性表现不佳的测试，幼犬检索，反映在大大延长检索laesthetic。腹侧纹状体DA耗竭对雌性性行为的感受性和接受性元素没有影响，这是在卵巢切除术和外源性卵巢激素给药后哺乳期研究的，但这些动物确实表现出对低剂量安非他明的减弱的多动反应。在背侧纹状体多巴胺损伤的女性没有显着差异，从控制方面的母亲和性行为，但他们确实表现出增强的多动反应安非他明治疗。
The effects of dopamine-depleting 6-OHDA infusions in the ventral or dorsal striatum on maternal and sexual behaviors were examined in female rats. Like sham-operated controls, lactating rats receiving 6-OHDA in the ventral striatum built good nests, nursed the infants and showed maternal aggression toward strange intruders. By contrast, the lesioned females performed poorly in tests for pup retrieval, as reflected in greatly protracted retrieval latencies. There was no effect of ventral striatal DA depletions on proceptive and receptive elements of female sexual behavior, which was studied after lactation following ovariectomy and exogenous administration of ovarian hormones, but these animals did show an attenuated hyperactivity response to a low dose of amphetamine. Females with dopamine lesions in the dorsal striatum did not differ from controls with respect to maternal and sexual behavior, but they did show an enhanced hyperactivity response to amphetamine treatment.