Single-pass continuous flow peritoneal dialysis using two catheters
Single-pass continuous flow peritoneal dialysis using two catheters
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DOI：
10.1046/j.1525-139x.2001.00098.x
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发表时间：
2001-09-01
影响因子：
1.6
通讯作者：
Diaz-Buxo, JA
中科院分区：
文献类型：
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作者：
Cruz, C;Melendez, A;Diaz-Buxo, JA
随着人们对连续流动腹膜透析 (CFPD) 重新产生兴趣，我们在面临通路失败的患者中植入第二根导管的标准做法为我们提供了对这些患者进行 CFPD 急性研究的机会，因为它暂时为我们提供了两根导管。研究了四名患者，总共进行了五项研究。遵循标准方案，使用 1.5% 葡萄糖溶液、2 L 填充、200 ml/min 的流入速率和按比例流出的 4 小时疗程。研究结束时进行完全引流。我们的结果为我们提供了尿素 (K-peU) 和肌酐 (K-peCr) 的平均有效腹膜清除率分别为 40 ml/min 和 28 ml/min，平均超滤率 (Q(f)) 为 13.4 ml/min。我们的尿素平均传质系数 (MTC) 为 40 毫升/分钟，与动力学模型和历史数据一致。获得的 K-pe、MTC 和 Q(f) 明显高于其他研究人员，这可能是通过两个单独的导管获得的结果导致透析液充分混合所致。这些临床结果为这种PD模式的未来发展奠定了坚实的基础。
With a renewed interest in continuous flow peritoneal dialysis (CFPD), our standard practice of implanting a second catheter in those patients facing access failure provided us the opportunity to perform acute studies on CFPD in these patients, since it temporarily provided us with two catheters. Four patients were studied, with a total of five studies performed. A standard protocol was followed utilizing 1.5% dextrose solution, a 2 L fill, an inflow rate of 200 ml/min with a proportionate outflow for a 4-hour session. A full drain was performed at the end of the study. Our results provided us with a mean effective peritoneal clearance for urea (K-peU) and creatinine (K-peCr) of 40 ml/min and 28 ml/min, respectively, and a mean ultrafiltration rate (Q(f)) of 13.4 ml/min. Our average mass transfer coefficient (MTC) for urea was 40 ml/min, consistent with kinetic modeling and historical data. The K-pe, MTC, and Q(f) achieved are significantly higher than other investigators, which could possibly be explained by those obtained by two separate catheters resulting in adequate mixing of the dialysate. These clinical results provide a solid foundation for the future development of this PD modality.