Quantifying optical microangiography images obtained from a spectral domain optical coherence tomography system.
Quantifying optical microangiography images obtained from a spectral domain optical coherence tomography system.
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DOI：
10.1155/2012/509783
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发表时间：
2012
影响因子：
7.6
通讯作者：
Wang R
中科院分区：
文献类型：
--
作者：
Reif R;Qin J;An L;Zhi Z;Dziennis S;Wang R
已知血管形态与几种疾病（例如癌症）相关，并且对于描述几种组织生理过程（例如血管生成）是重要的。因此，用于表征从医学图像获得的血管造影的定量方法将具有若干临床应用。光学微血管造影术（OMAG）是一种用于获得组织体积内血管三维图像的方法。在这项研究中，我们建议量化OMAG图像获得的光谱域光学相干断层扫描系统。提出并验证了一种确定三个可测量参数（分形维数，血管长度分数和血管面积密度）的技术。最后，确定了获取OMAG图像的可重复性，并提出了一种从这些图像中分析小区域的新方法。
The blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clinical applications. Optical microangiography (OMAG) is a method for obtaining three-dimensional images of blood vessels within a volume of tissue. In this study we propose to quantify OMAG images obtained with a spectral domain optical coherence tomography system. A technique for determining three measureable parameters (the fractal dimension, the vessel length fraction, and the vessel area density) is proposed and validated. Finally, the repeatability for acquiring OMAG images is determined, and a new method for analyzing small areas from these images is proposed.