LASSA VIRUS ISOLATION FROM MASTOMYS NATALENSIS RODENTS DURING AN EPIDEMIC IN SIERRA-LEONE
LASSA VIRUS ISOLATION FROM MASTOMYS NATALENSIS RODENTS DURING AN EPIDEMIC IN SIERRA-LEONE
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DOI：
10.1126/science.185.4147.263
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发表时间：
1974-01-01
期刊：
影响因子：
56.9
通讯作者：
CACCIAPU.A
中科院分区：
文献类型：
--
作者：
MONATH, TP;NEWHOUSE, VF;CACCIAPU.A
拉沙热是一种严重的发热性疾病，于1969年首次在西非发现。在塞拉利昂的一次流行期间，首次从野生啮齿动物Mastomys natalensis中分离到拉沙病毒。在拉沙热患者居住的房屋中发现了高感染率的乳腺癌。所提供的数据首次证明了拉沙病毒传播的人外循环，并表明啮齿动物控制可能是限制该疾病的有效方法。
Lassa fever is a severe febrile illness of man, first recognized in West Africa in 1969. During an epidemic in Sierra Leone, Lassa virus was isolated for the first time from wild rodents ofMastomys natalensis. A high prevalence of infectedMastomyswas found in houses occupied by patients with Lassa fever. The data presented provide the first demonstration of an extra-human cycle of Lassa virus transmission and suggest that rodent control may be an effective method of limiting the disease.