Scoliosis in twins - A meta-analysis of the literature and report of six cases
Scoliosis in twins - A meta-analysis of the literature and report of six cases
复制标题
DOI：
10.1097/00007632-199709010-00014
复制
发表时间：
1997-09-01
期刊：
影响因子：
3
通讯作者：
Reinker, KA
中科院分区：
文献类型：
--
作者：
Kesling, KL;Reinker, KA
研究设计。这项研究是对世界上有关单卵和异卵双胞胎青少年特发性脊柱侧凸文献的荟萃分析。此外，还报告了6例双胞胎脊柱侧弯的病例。比较同卵和异卵双生子与青少年特发性脊柱侧弯的一致性、严重程度和曲线模式，试图记录青少年特发性脊柱侧凸的遗传病因和遗传模式。背景数据总结，有大量的双胞胎青少年特发性脊柱侧凸的病例报告，然而，这些数据以前没有作为一个单一的数据库进行分析。方法：研究方法。检索双胞胎青少年特发性脊柱侧弯的病例，增加作者治疗的6例病例。发现了100对双胞胎，其中68对有足够的数据进行比较分析。对每组患者的单合子、脊柱侧弯的一致性、曲度类型和曲度进行评估。37对双胞胎为单合子，31对为杂合子。同卵双胞胎的符合率为73%，异卵双胞胎的符合率为36%。在P<；0.003指数中，这一差异具有统计学意义。20对同卵双胞胎和16对异卵双胞胎的曲线严重程度可以进行比较。同卵双生子之间的相关系数r=0.399(P<；0.126)。曲线型比较无统计学意义。同卵双胞胎的符合率明显高于异卵双胞胎，并且同卵双胞胎的曲线一起发展和进步。基于这些数据，有强有力的证据表明青少年特发性脊柱侧弯的遗传病因。
Study Design. This study is a meta-analysis of the world's literature on adolescent idiopathic scoliosis in monozygotic and dizygotic twins. Additionally, six previously unreported cases of scoliosis in twins are presented.Objectives. To compare and contrast the concordance, severity, and curve patterns in monozygotic and dizygotic twins with adolescent idiopathic scoliosis in an attempt to document a genetic etiology and delineate inheritance patterns for adolescent idiopathic scoliosis.Summary of Background Data, There are numerous case reports of twins sets with adolescent idiopathic scoliosis, However, this data has not been previously analyzed as a single data base. Methods. The literature was searched for cases of twins with adolescent idiopathic scoliosis, and six cases of patients treated by authors were added. One hundred cases of sets of twins were discovered, 68 of which had sufficient data for comparative analysis. Each set was evaluated for monozygosity, concordance of scoliosis, curve pattern, and severity of curve.Results. Thirty-seven sets of twins were monozygous, and 31 sets were dizygous. Concordance was 73% among monozygous twins and 36% among dizygous twins. The difference is statistically significant at P < 0.003. Curve severity could be compared in 20 sets of monozygous twins and 16 sets of dizygous twins. Among monozygous twins, there was a correlation coefficient of r = 0.399 (P < 0.126). Curve pattern comparison was not statistically significant.Conclusions. Monozygous twins have a significantly higher rate of concordance than dizygous twins, and the curves in monozygous twins develop and progress together. Based on these data, there is strong evidence for a genetic etiology for adolescent idiopathic scoliosis.