Etiology of hepatocellular carcinoma in Latin America: a prospective, multicenter, international study
Etiology of hepatocellular carcinoma in Latin America: a prospective, multicenter, international study
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DOI：
10.1016/s1665-2681(19)31681-3
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发表时间：
2010-01-01
影响因子：
3.8
通讯作者：
Pinchuk, Leonardo
中科院分区：
文献类型：
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作者：
Fassio, Eduardo;Diaz, Solangel;Pinchuk, Leonardo
背景/目的。在拉丁美洲，尚无前瞻性研究调查HCC的病因。本前瞻性研究的主要目的是分析本地区HCC患者肝脏疾病的病因学。次要目的是使用Okuda和BCLC分类评估分期；以及接受治疗的患者百分比。方法。拉丁美洲肝脏研究协会理事会设计了该方案。在18个月的时间里，所有成员都被邀请在网上下载他们的HCC事件病例。结果：共上传9个国家的240例病例，其中男性174例（72.5%），中位年龄64岁，四分位数范围57 ~ 72。85.4%的患者有肝硬化。主要病因为：HCV 74例（30.8%），酒精49例（20.4%），隐源性肝硬化35例（14.6%），HBV 26例（10.8%），HCV +酒精14例（5.8%）。考虑到联合用药，91例（38%）患者出现丙型肝炎；慢性酒精中毒68例（28%）；33例（14%）为乙型肝炎。两组在诊断年龄上无显著差异。酒精组（94%）、HCV +酒精组（93%）和HBV组（85%）的男性比例高于隐源性肝硬化组（60%）和HCV组（59%）(p
Background/aims. No prospective study has been published investigating etiology of HCC in Latin America. The primary aim of this prospective study was to analyze the etiology of liver disease in patients with HCC from our area. Secondary aims were to evaluate staging using Okuda and BCLC classifications; and percentage of patients receiving treatment. Methods. The Governing Board of the Latin American Association for the Study of the Liver designed the protocol. During a 18 month period, all members were invited to load their incident HCC cases on line. Results. 240 cases from 9 countries were uploaded, 174 were male (72.5%), median age was 64 years, interquartile range 57-72. In 85.4% of cases, patients had underlying cirrhosis. Main etiological factors were: HCV in 74 patients (30.8%), alcohol in 49 (20.4%), cryptogenic cirrhosis in 35(14.6%), HBV in 26 (10.8%), HCV plus alcohol in 14 (5.8%). Considering the combinations, hepatitis C was shown in 91 patients (38%); chronic alcoholism in 68 patients (28%); and hepatitis B in 33 patients (14%). There were no significant differences between the groups in the age at diagnosis. Percentage of male gender was higher in groups of alcohol (94%), HCV plus alcohol (93%) and HBV (85%) than in cryptogenic cirrhosis (60%) and HCV (59%) (p