Longitudinal study of risk factors for coronary heart disease across the menopausal transition
Longitudinal study of risk factors for coronary heart disease across the menopausal transition
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DOI：
10.1093/oxfordjournals.aje.a010246
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发表时间：
2000-03-15
影响因子：
5
通讯作者：
Dennerstein, L
中科院分区：
文献类型：
--
作者：
Do, KA;Green, A;Dennerstein, L
1991年至1995年，对澳大利亚墨尔本的150名中年妇女进行了一项纵向研究，研究了血脂、舒张压、体重指数、吸烟和饮酒行为以及运动的变化模式。参照末次月经时间（FMP）检查风险因素随时间的变化。随机效应模型拟合了重复测量和其他协变量（包括年龄）的调整。绝经前3年和绝经后3年之间低密度脂蛋白胆固醇总体净增加0.25 mmol/L，高密度脂蛋白胆固醇（HDL胆固醇）为0.05 mmol/L，甘油三酯为0.34 mmol/L，体重指数为0.12 kg/m2，舒张压为0.48 mmHg。饮酒者的比例下降了13%，吸烟者的比例增加了17%，每周至少锻炼一次的女性的比例增加了6%，唯一依赖于FMP的变化是HDL胆固醇的显着下降（在FMP前一年中，HDL胆固醇的类似升高抵消了这一点），并且在月经停止后约9个月，降低率最大，斜率的瞬时估计值为0.55 mmol/L/年。
The patterns of change in blood lipids, diastolic blood pressure, body mass index, smoking and drinking behaviors, and exercise were examined in an ongoing longitudinal study from 1991 to 1995 of 150 middle-aged Melbourne, Australia, women as they passed through menopause. Changes in risk factors over time were examined with reference to time of the final menstrual period (FMP), Random effects models were fitted with adjustments for repeated measures and other covariates, including age, There were overall net increases between 3 years before and the 3 years after menopause of 0.25 mmol/liter for low density lipoprotein cholesterol, 0.05 mmol/liter for high density lipoprotein cholesterol (HDL cholesterol), 0.34 mmol/liter for triglycerides, 0.12 kg/m(2) for body mass index, and 0.48 mmHg for diastolic pressure. The proportion of drinkers decreased by 13%, that of smokers increased by 17%, and that of women who exercised at least once a week increased by 6%, The only change dependent on the FMP was a significant decrease in HDL cholesterol (counterbalanced by a similar rise in HDL cholesterol in the year before the FMP), and the rate of decrease was maximal around 9 months after menses ceased, with an instantaneous estimate of slope of 0.55 mmol/liter per year.