THE PRODUCTION OF SHOCK BY THE PROLONGED CONTINUOUS INJECTION OF ADRENALIN IN UNANESTHETIZED DOGS
THE PRODUCTION OF SHOCK BY THE PROLONGED CONTINUOUS INJECTION OF ADRENALIN IN UNANESTHETIZED DOGS
复制标题
长时间连续注射肾上腺素对未麻醉的狗产生休克
DOI：
10.1152/ajplegacy.1940.131.3.545
复制
发表时间：
1940
影响因子：
--
通讯作者：
C. Miller
中科院分区：
文献类型：
--
作者：
N. E. Freeman;H. Freedman;C. Miller
方法. 12至18.8公斤的成年犬。用了他们被训练安静地侧卧，并被发现在蒙上眼睛的情况下保持这种姿势最好。通过在局部麻醉下插入的插管直接从左股动脉或左肱动脉记录血压，插管连接有动脉测压计。根据Freeman和Zeller（7）的方法，用体积描记器测量右后爪的血流速度。用Sahli血红蛋白计测量从右耳获得的血液的血红蛋白浓度。在实验开始时和第二次血浆体积测定开始时，对来自右颈静脉的肝素化血液进行红细胞压积测定。血浆体积测定用染料T-1824（Gregersen，吉布森和Stead，10;吉布森和Evans，8）进行，然后进行血浆体积测定。
METHODS. Adult dogs of 12 to 18.8 kgm. were used. They were trained to lie quietly on their sides and were found to remain in this position best while blindfolded. Blood pressure was recorded directly from the left femoral or left brachial artery by means of a cannula, inserted under local anesthesia, connected with a tambour manometer. The rate of blood flow in the right hind paw was measured with a plethysmograph according to the method of Freeman and Zeller (7). Hemoglobin concentrations were measured with a Sahli hemoglobinometer on blood obtained from the right ear. Hematocrit determinations were made on hepariniaed blood from the right jugular vein at the beginning of the experiment and again at the time when the second plasma volume determination was started. The plasma volume determinations were made with the dye T-1824 (Gregersen, Gibson and Stead, 10; Gibson and Evans, 8) before the