SUPPLEMENTATION OF ASCORBIC ACID AND ALPHA-TOCOPHEROL IS USEFUL TO PREVENTING BONE LOSS LINKED TO OXIDATIVE STRESS IN ELDERLY
SUPPLEMENTATION OF ASCORBIC ACID AND ALPHA-TOCOPHEROL IS USEFUL TO PREVENTING BONE LOSS LINKED TO OXIDATIVE STRESS IN ELDERLY
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DOI：
10.1007/s12603-010-0099-5
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发表时间：
2010-01-01
影响因子：
5.8
通讯作者：
Mendoza-Nunez, V. M.
中科院分区：
文献类型：
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作者：
Ruiz-Ramos, M.;Alberto Vargas, L.;Mendoza-Nunez, V. M.
目的：探讨抗坏血酸和α-生育酚对老年人氧化应激和骨密度的影响。设计图：在90名老年受试者的样本中进行了双盲对照临床试验，这些受试者被分为三个年龄配对的随机组，每组30名受试者。Tx 0组接受安慰剂，Tx 1组接受500 mg抗坏血酸和400 IU α-生育酚，而Tx 2组接受1，000 mg抗坏血酸和400 IU α-生育酚，为期12个月。测量值：我们测量了硫代巴比妥酸反应物质（TBARS）、总抗氧化状态（TAS）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）;在补充维生素C和E的12个月治疗期前后，通过DXA获得髋部和脊柱的BMD。结果：髋部骨密度与SOD呈正相关（r = 0.298，p
Objective: To determine the effect of ascorbic acid and alpha-tocopherol on oxidative stress and bone mineral density (BMD) in elderly people. Design: A double-blind, controlled clinical assay was carried out in a sample of 90 elderly subjects divided into three age-paired random groups with 30 subjects in each group. Group Tx0 received placebo, group Tx1 received 500 mg of ascorbic acid and 400 IU of alpha-tocopherol, whereas group Tx2 received 1,000 mg of ascorbic acid and 400 IU of alpha-tocopherol, for a 12-month period. Measurements: We measured thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), superoxide dismutase (SOD), and glutation peroxidase (GPx); BMD was obtained on DXA of hip and spine before and after the 12-month treatment period with supplementation of vitamins C and E. Results: We found a positive correlation between hip-BMD and SOD (r = 0.298, p