TADDOL-based phosphorus(III)-ligands in enantioselective Pd(0)-catalysed C-H functionalisations.
TADDOL-based phosphorus(III)-ligands in enantioselective Pd(0)-catalysed C-H functionalisations.
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DOI：
10.1039/c5cc07929b
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发表时间：
2015-12
影响因子：
4.9
通讯作者：
J. Pedroni;N. Cramer
中科院分区：
文献类型：
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作者：
J. Pedroni;N. Cramer
单齿TADDOL衍生的亚磷酰胺和亚膦酸酯是用于对映选择性Pd（0）催化的C-H官能化的通用手性配体。它们能够实现高度选择性的环化，以获得广泛的手性碳环和杂环。这种配体类的高吸引力在于它们的模块化结构，允许快速组装具有可变空间特性的文库。介绍了利用基于Pd（0）络合物和TADDOL型配体的催化体系的不对称C-H官能化方法，并讨论了选择性方面。
Monodentate TADDOL-derived phosphoramidites and phosphonites are versatile chiral ligands for enantioselective Pd(0)-catalysed C-H functionalisations. They enable highly selective cyclisations to access a wide range of chiral carbo- and heterocycles. The high attractiveness of this ligand class consists in their modular structure, allowing for a quick assembly of a library with variable steric properties. Asymmetric C-H functionalisation methods utilising catalytic systems based on Pd(0) complexes and TADDOL-type ligands are presented and aspects of selectivity are discussed.