TRANSMISSION OF IMMUNITY FROM MOTHER TO YOUNG AND CATABOLISM OF IMMUNOGLOBULINS
TRANSMISSION OF IMMUNITY FROM MOTHER TO YOUNG AND CATABOLISM OF IMMUNOGLOBULINS
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DOI：
10.1016/s0140-6736(66)92190-8
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发表时间：
1966-01-01
期刊：
影响因子：
168.9
通讯作者：
BRAMBELL, FW
中科院分区：
文献类型：
--
作者：
BRAMBELL, FW
我想在这里回顾的工作大约是在二十年前开始的。H.米尔斯和我正在合作解决另一个问题。我们注意到，纤维蛋白原存在于早期兔胚胎植入后不久的囊胚腔（卵黄囊）中（Brambell和米尔斯，1947）。看来这种纤维蛋白原一定是母体来源的，因为它在血液循环建立之前就存在于胚胎中。就其蛋白质含量而言，该液体类似于相当稀释的血浆，并含有母体循环抗体（Brambell等人，1949）。
THE work which I would like to review here began about twenty years ago when Prof. I. H. Mills and I were collaborating on another problem. We noticed that fibrinogen was present in the fluid filling the blastocyst cavity (the yolk-sac) of the early rabbit embryo shortly after it had become implanted (Brambell and Mills 1947). It seemed that this fibrinogen must be of maternal origin, since it was present in the embryo before the circulation was established. With respect to its protein content this fluid resembled rather dilute blood-plasma and contained maternal circulating antibodies (Brambell et al. 1949).